Evidence map›Paper›PMID 41702422›Full record

ArticlePediatrics2026

Patterns of Children With Complex Chronic Conditions: A Latent Class Analysis.

Eyal Cohen, Maria Osipovich, Hallie Benjamin, Nathaniel D Bayer, Christian D Pulcini, Jeffrey D Colvin, Ryan J Coller, Jana C Leary, Sarah Malecki, John M Morrison and 2 more

Abstract read
In one paragraph

Article in Pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Hospital-to-home transitions for children with medical complexity.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Eyal CohenEdwin S.H. Leong Centre for Healthy Children, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Maria OsipovichDivision of General Pediatrics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Hallie BenjaminChild Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada.
Nathaniel D BayerDivision of Pediatric Hospital Medicine, Department of Pediatrics, Golisano Children's Hospital, University of Rochester, Rochester, New York.
Christian D PulciniDepartment of Emergency Medicine and Pediatrics, University of Vermont Medical Center and Children's Hospital, University of Vermont Larner College of Medicine, Burlington, Vermont.
Jeffrey D ColvinDivision of General Academic Pediatrics, Children's Mercy Hospital, University of Missouri-Kansas City, Kansas City, Missouri.
Ryan J CollerDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
Jana C LearyDivision of General Pediatrics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Sarah MaleckiInstitute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.
John M MorrisonDepartment of Pediatrics, John Hopkins All Children's Hospital, Saint Petersburg, Florida.
Matt HallChildren's Hospital Association, Lenexa, Kansas.
Jay G BerryDivision of General Pediatrics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Funding

Institutional Career Development CoreKL2TR001999 · NCATS · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2016 to 2024
$5.2M
Prognostic modeling of pediatric tracheostomy-associated respiratory tract infectionsK23HL163331 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI John M Morrison · 2023 to 2026
$790k
Optimization and Implementation Trial of a User-Centered Emergency Care Planning Tool for Infants with Medical ComplexityK23HD109469 · NICHD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Christian Donald Pulcini · 2022 to 2026
$777k
Social Risk Screening and Referral Implementation for All Pediatric Hospitals – The SOCIAL-H StudyK23HD113884 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Jana Leary · 2025 to 2026
$316k
NCATS NIH HHS KL2 TR001999NHLBI NIH HHS K23 HL163331NICHD NIH HHS K23 HD109469NICHD NIH HHS K23 HD113884
6 · The paper itself

Abstract

objectivesThe objective of this study was to distinguish empirical classes among children with complex chronic conditions (CCCs) and to assess whether such classes can predict future health care use.

methodsWe analyzed claims data from children aged 1 to 18 years with a CCC who were continuously enrolled in a 10-state Medicaid database from 2017 to 2019. We performed a latent class analysis using demographic factors, clinical characteristics, and health care use patterns in 2017 and assessed the ability of the classes to differentiate health care spending and use in 2018 to 2019 using negative binomial and logistic regression.

resultsWe included 185 672 children with a CCC (52% male; median [IQR] age: 11 [5, 15] years). Eight indicator variables led to a 3-class solution (entropy = 0.83): Class 1 (9.1% of the cohort) was characterized by high neuro-disability, high technology dependence, and high multimorbidity; Class 2 (14.8%) had high neuro-disability and low technology dependence; and Class 3 (76.0%) had low neuro-disability and low technology dependence. Compared with children in Class 3, total spending in 2017 to 2018 was increased among both Class 1 and Class 2 (total spending rate ratio [RR] 6.9 [95% CI: 6.7-7.0] and RR 2.5 [95% CI: 2.5-2.6], respectively). The largest categories of subsequent spending were for inpatient care and outpatient specialist services among individuals in Class 1 and for outpatient drugs, outpatient specialists, and mental health for those in Class 2.

conclusionsChildren with CCCs can be categorized into meaningful classes based on readily available data with different patterns of future health care use and costs.

Indexed as

Latent Class AnalysisPatient Acceptance of Health CareAdolescentChildChild, PreschoolChronic DiseaseFemaleHealth ExpendituresHumansInfantMaleMedicaidUnited States

Identifiers

PMID41702422
PMCPMC13584193

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.