Evidence map›Paper›PMID 41702372›Full record

ArticleJournal of applied toxicology : JAT2026

Human Neurotoxicity of Trichloroethylene: A Biomarker Approach.

Lütfiye Tutkun, Meşide Gündüzöz, Murat Büyükşekerci, Osman Gökhan Özakıncı, Gülsüm Abuşoğlu, Mustafa Polat, Servet Birgin İritaş, Vugar Ali Türksoy, Engin Tutkun

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In one paragraph

Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lütfiye TutkunThe Association of Industrial Toxicology and Occupational Hygiene, Ankara, Türkiye.ORCID 0000-0002-8333-7404
Meşide GündüzözDepartment of Family Medicine, University of Health Sciences, Atatürk Sanatoryum Training and Research Hospital, Ankara, Türkiye.ORCID 0000-0001-6140-8331
Murat BüyükşekerciPharmacology Clinic, Ankara Gazi Mustafa Kemal Occupational and Environmental Diseases Hospital, Ankara, Türkiye.ORCID 0000-0001-9921-0507
Osman Gökhan ÖzakıncıWake Forest University, Winston-Salem, North Carolina, USA.ORCID 0000-0001-5344-3305
Gülsüm AbuşoğluDepartment of Medical Laboratory Techniques, Vocational School of Health Sciences, Selçuk University, Konya, Türkiye.ORCID 0000-0003-1630-1257
Mustafa PolatDepartment of Family Medicine, University of Health Sciences, Atatürk Sanatoryum Training and Research Hospital, Ankara, Türkiye.
Servet Birgin İritaşDepartment of Forensic Medicine, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.ORCID 0000-0001-5283-9973
Vugar Ali TürksoyDepartment of Public Health, Faculty of Medicine, Yozgat Bozok University, Yozgat, Türkiye.ORCID 0000-0002-3545-3945
Engin TutkunTez Medikal Institute of Occupational Health and Safety, Ankara, Türkiye.ORCID 0000-0003-2215-0424

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Occupational exposure to organic solvents remains a significant neurotoxic risk, yet early biochemical indicators of neural injury are insufficiently characterized. This cross-sectional study evaluated 86 automotive spray painters and 85 controls to investigate the relationship between solvent metabolites and neurotoxic biomarkers. Serum S100B, NSE, MAP 2, GFAP, and MBP were measured alongside urinary metabolites, including trichloroacetic acid (TCA), phenol, mandelic acid, phenylglyoxylic acid, and 2,5-hexanedione. Exposed workers showed significantly higher concentrations of all neural injury markers. TCA levels were markedly elevated and demonstrated strong correlations with S100B, NSE, MAP 2, GFAP, and MBP. Multiple regression analyses identified TCA as the only independent predictor across all biomarkers, indicating a dominant role of chlorinated solvent pathways in early neural injury. These findings suggest that solvent exposure-particularly to chlorinated compounds-elicits subclinical glial, neuronal, cytoskeletal, and myelin disturbances. Biomarker profiling may support early detection and prevention strategies in solvent-exposed workers.

Indexed as

Neurotoxicity SyndromesOccupational ExposureSolventsTrichloroethyleneAdultBiomarkersCross-Sectional StudiesFemaleGlial Fibrillary Acidic ProteinHumansMaleMiddle AgedPhosphopyruvate HydrataseS100 Calcium Binding Protein beta SubunitTrichloroacetic AcidBiomarkersGFAP protein, humanGlial Fibrillary Acidic ProteinPhosphopyruvate HydrataseS100B protein, humanS100 Calcium Binding Protein beta SubunitSolventsTrichloroacetic AcidTrichloroethylenebiomarkersGFAPneurotoxicityorganic solventsS100Btrichloroethylene

Identifiers

PMID41702372
PMCPMC13432740

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.