Evidence map›Paper›PMID 41702341›Full record

ArticlePoultry science2026

HDAC1 and SATB1 positively regulate immune responses in chicken macrophages.

Bowen Niu, Junda Hu, Zixuan Fan, Zihao Gao, Yuchen Jie, Xinyu Wu, Xingying Chen, Sirui Chen, Li-Wa Shao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bowen NiuState Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China; Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Junda HuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Zixuan FanState Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China; Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Zihao GaoTsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China; National Institute of Biological Sciences, Beijing 102206, China.
Yuchen JieState Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China; Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Xinyu WuState Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China; Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Xingying ChenState Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China; Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Sirui ChenState Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China; Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. Electronic address: csr@cau.edu.cn.
Li-Wa ShaoState Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China; Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. Electronic address: liwa@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The avian immune system constitutes the primary barrier against pathogen invasion, and its regulatory efficiency directly determines animal health, productive performance, and food safety. Elucidating the molecular and cellular networks that maintain immune homeostasis in poultry has therefore become a pivotal entry point for improving disease prevention and achieving environmentally sustainable production. Histone deacetylase 1 (HDAC1) and special AT-rich sequence-binding protein 1 (SATB1) are reported modulators of immunity in some species such as mammals, yet their roles in avian species remain undefined. Here, we employed chicken macrophages (HD11) stimulated with lipopolysaccharide (LPS) to establish an in vitro immune-response model. Both HDAC1 and SATB1 were markedly activated and up-regulated upon LPS challenge. Using cell transfection and CRISPR/Cas9 genome editing, we generated HD11 cell lines with stable disruption of either HDAC1 or SATB1. In these modified cells, the LPS-induced elevation of key immune effectors-including IFN-β, IRF7, STAT1, TNF-α, and IFIH1 was significantly attenuated. Amino-acid sequence alignment, protein complex prediction, and co-immunoprecipitation further suggest that HDAC1 and SATB1 are evolutionarily conserved and physically interact. Collectively, our study uncovers a novel mechanism by which HDAC1 and SATB1 act synergistically to positively regulate immune responses in chicken macrophages. These findings not only provide new theoretical insights into avian immune regulation but also establishes a molecular foundation for the development of next-generation immune enhancers and breeding strategies that enhance disease resistance.

Indexed as

Avian ProteinsChickensHistone Deacetylase 1Immunity, InnateMacrophagesMatrix Attachment Region Binding ProteinsAnimalsLipopolysaccharidesAvian ProteinsHistone Deacetylase 1LipopolysaccharidesMatrix Attachment Region Binding ProteinsChicken macrophageHDAC1Immune regulationLipopolysaccharideSATB1

Identifiers

PMID41702341
PMCPMC12925555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.