ArticleProceedings of the National Academy of Sciences of the United States of America2026
Stability of epigenetic transgenerational inheritance of adult-onset disease and parturition abnormalities.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Article
- BPA-induced differential methylation of the androgen receptor promoter CpG island in medaka germline and somatic cells.Environmental epigenetics · 2026Article
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Authors and funding
4 authors.
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Abstract
Previous research on the generational stability of epigenetic transgenerational inheritance was conducted through a ten-generation study of all transgenerational generations in mammals. This study demonstrated both the stability of epigenetic inheritance across generations and demonstrated a generational increase incidence of disease pathology. Building on this research, the present study follows the same lineage of rats with ancestral vinclozolin exposure through twenty generations. The findings offer important insights into long-term mammalian models of epigenetic transgenerational inheritance. Observations demonstrate an increase in differential DNA methylated regions across multiple generations. This indicates a persistent and stable transmission of epigenetic alterations. Additionally, deoxyuridine triphosphate (dUTP) transferase-mediated nick end labeling apoptosis assays revealed elevated levels of germline apoptosis in the male rats of the maternal and paternal lineages. This suggests a potential consequence of epigenetic dysregulation in spermatogenesis. Ancestrally exposed rats to vinclozolin showed significant parturition abnormalities in both the maternal and paternal lineages after 16 generations. This included maternal deaths during labor and stillbirths. Pathological assessments revealed abnormalities across multiple tissue types and an increased incidence of disease. This suggests the physiological consequences of the generational stability of epigenetic inheritance. Observations establish the generational stability of epigenetic inheritance over twenty generations in a mammalian model system; however, new pathology in later generations involving parturition abnormalities was also observed. The generational stability of transgenerational effects observed in this study has implications for human health, particularly regarding environmental toxicant exposures, reproductive health disorders, and disease susceptibility.
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