Evidence map›Paper›PMID 41701829›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.

Bola S Hanna, P Kent Langston, Miguel Marin-Rodero, Ricardo N Ramirez, Min Wan, Christophe Benoist, Diane Mathis

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bola S Hanna *Department of Immunology, Harvard Medical School, Boston, MA 02115.
P Kent Langston *Department of Immunology, Harvard Medical School, Boston, MA 02115.
Miguel Marin-RoderoDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Ricardo N RamirezDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Min WanInternal Medicine Research Unit, Worldwide Research, Development and Medical, Pfizer Inc., Cambridge, MA 02139.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA 02115.

Funding

Adipose-tissue Tregs: important players in immunological control of metabolismR01DK092541 · NIDDK · HARVARD MEDICAL SCHOOL · PI DIANE J MATHIS · 2011 to 2026
$6.4M
Freedom Together Foundation (FTF) NAHHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK092541NIDDK NIH HHS R01 DK092541Pfizer Inc NA
6 · The paper itself

Abstract

Metabolic-dysfunction-associated steatohepatitis (MASH) is a chronic liver disease driven by the confluence of metabolic stress and destructive inflammation. The immunoregulatory mechanisms that temper this process remain poorly understood. Multipronged data on a complementary pair of murine MASH models and published single-cell RNA-sequencing datasets from MASH patients revealed a critical protective role for Foxp3

Indexed as

Fatty LiverLiverT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalForkhead Transcription FactorsHumansMicePPAR gammaForkhead Transcription FactorsPPAR gammaliverMASHregulatory T cellssteatohepatitisTregs

Identifiers

PMID41701829
PMCPMC12933153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.