Evidence map›Paper›PMID 41701727›Full record

ArticlePLoS computational biology2026

Ten common misconceptions about Galaxy (and why they are wrong!).

Wendi Anne Bacon, Bérénice Batut, Sanjay Kumar Srikakulam, Paul Zierep, Anthony Bretaudeau, Björn Grüning, Gildas Le Corguillé, Helge Hecht, John Y Davis, Hans-Rudolf Hotz and 1 more

Abstract read
In one paragraph

Article in PLoS computational biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wendi Anne BaconLife Health & Chemical Sciences, The Open University, Milton Keynes, United Kingdom.ORCID https://orcid.org/0000-0002-8170-8806
Bérénice BatutIFB-core, Institut Français de Bioinformatique (IFB), CNRS, INSERM, INRAE, CEA, Villejuif, France.
Sanjay Kumar SrikakulamLife Health & Chemical Sciences, The Open University, Milton Keynes, United Kingdom.
Paul ZierepAlbert-Ludwigs-Universität Freiburg: Freiburg im Breisgau, Baden-Württemberg, Germany.
Anthony BretaudeauGenOuest, Univ Rennes, Inria, CNRS, IRISA, Rennes, France.
Björn GrüningAlbert-Ludwigs-Universität Freiburg: Freiburg im Breisgau, Baden-Württemberg, Germany.
Gildas Le CorguilléABiMS Platform, Station Biologique de Roscoff, CNRS, Sorbonne Université, Roscoff, France.
Helge HechtFaculty of Science, Masaryk University, RECETOX, Brno, Czech Republic.
John Y DavisDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America.ORCID https://orcid.org/0000-0002-1363-1245
Hans-Rudolf HotzFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID https://orcid.org/0000-0002-2799-424X
Beatriz Serrano-SolanoEuro-BioImaging ERIC Bio-Hub, EMBL Heidelberg, Heidelberg, Germany.

Funding

The AnVIL Data Ecosystem DACReS SupplementU24HG010262 · NHGRI · BROAD INSTITUTE, INC. · PI Robert J Carroll, Jonathan Lawson · 2018 to 2026
$40.5M
Implementing the Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL)U24HG010263 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI Enis Afgan, VINCENT JAMES CAREY · 2018 to 2026
$23.8M
An in integrated platform for multiomic analyses of pathogen and host data using scalable public infrastructureU24AI183870 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI Kelsey M Beavers, Maximilian Haeussler · 2024 to 2026
$10.2M
Democratization of Data Analysis in Life Sciences Through GalaxyU24HG006620 · NHGRI · PENNSYLVANIA STATE UNIVERSITY, THE · PI Daniel James Blankenberg, Jeremy Goecks · 2021 to 2026
$9.8M
The CFDE Cloud WorkspaceOT2OD037936 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI James Paul Carson, ANTON NEKRUTENKO · 2024 to 2026
$4.9M
Developing a Cancer Galaxy Computational Workbench to Meet Emerging Cancer Data Analysis NeedsU24CA284167 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Jeremy Goecks · 2024 to 2026
$2.9M
NCI NIH HHS U24 CA284167NHGRI NIH HHS U24 HG006620NHGRI NIH HHS U24 HG010262NHGRI NIH HHS U24 HG010263NIAID NIH HHS U24 AI183870NIH HHS OT2 OD037936
6 · The paper itself

Abstract

Galaxy is a widely used open-source platform for accessible, reproducible, transparent and scalable data analysis in the life sciences and beyond. Despite its growing adoption across domains, several misconceptions persist about its scope, usability, scalability and relevance to academia and industry. In this manuscript, we identify and address 10 common misconceptions about Galaxy, ranging from the belief that it is limited to genomics, lacks scalability, or is only useful for teaching, to doubts about its ability to support secure data analysis or maintain high software quality as a free and open-source project. We refute each misconception with present evidence based on Galaxy's technical features, real-world use cases, user communities and governance structures. We show that Galaxy is a mature and versatile platform capable of supporting cutting-edge scientific research, education and even clinical workflows across a wide variety of disciplines. By clarifying existing misconceptions, we aim to help researchers, educators, developers and decision-makers better appreciate Galaxy's capabilities and potential within their fields.

Indexed as

Computational BiologySoftwareGenomicsHumans

Identifiers

PMID41701727
PMCPMC12912617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.