Evidence map›Paper›PMID 41701419›Full record

ArticleMarine biotechnology (New York, N.Y.)2026

Whole-genome Resequencing Reveals the Sex Determination System and Develops a Sex-specific Marker in Fat Greenling (Hexagrammos otakii).

Duan Liao, Yangqing Zhang, Chunlong Miao, Shuo Li, Weijing Li, Chen Li, Ivana Felipe da Rosa, Lucas Benites Doretto, Yuyan Liu, Qian Wang and 3 more

Abstract read
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Article in Marine biotechnology (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Duan Liao *State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Yangqing Zhang *State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Chunlong MiaoState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Shuo LiState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Weijing LiState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Chen LiState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Ivana Felipe da RosaState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Lucas Benites DorettoState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Yuyan LiuState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Qian WangState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Kaiqiang LiuState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Hong-Yan WangState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Changwei ShaoState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China. shaocw@ysfri.ac.cn.

Funding

AoShan Talents Cultivation Program Supported by Qingdao National Laboratory for Marine Science and Technology 2017ASTCP-ES06Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences 2023TD19Key R&D Program of Hebei Province, China 21326307DKey Research and Development Project of Shandong Province 2024LZGC005National Key Research and Development Program of China 2022YFD2400100Taishan Scholars Program tstp20221149
6 · The paper itself

Abstract

Teleost fishes display remarkable diversity in sex determination mechanisms, yet this aspect remains uninvestigated in the family Hexagrammidae. In this study, we performed whole-genome resequencing of Hexagrammos otakii to characterize its sex determination system. Genome-wide association studies and population differentiation index analysis identified chromosome 9 as the sex chromosome, supporting a male heterogametic (XY) system. A 3.11 Mb sex-determining region (SDR) was delineated, containing the potential candidate gene gdf6a. Comparative genomic analysis revealed that the H. otakii sex chromosome is non-homologous to those reported in other Cottioidei species, suggesting an independent origin and a dynamic evolutionary trajectory. In addition, we identified a 99 bp male-specific deletion within the SDR and developed a PCR-based marker that successfully differentiates sex with 100% accuracy. This study provides the first characterization of a sex chromosome in Hexagrammidae and offers a practical tool for sex-controlled breeding and germplasm management in H. otakii.

Indexed as

FishesSex ChromosomesSex Determination ProcessesAnimalsGenetic MarkersGenome-Wide Association StudyMaleWhole Genome SequencingGenetic MarkersHexagrammos otakiiSex chromosomeSex determination systemSex-specific marker

Identifiers

PMID41701419

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.