Evidence map›Paper›PMID 41701406›Full record

ArticleBiochemical genetics2026

ERBB2 as a Prognostic Biomarker in Prostate Cancer: Integration of Single-Cell Transcriptomics, Deep Learning, and Immunohistochemical Validation.

Chen Wang, Li-Jing Zhu, Wei-Bo Mao, Ting Chen, Teng-Fei Gu, Sheng-Ping Hu, Yong-Tao Pan, Guo-Lin Yan, Yun-Peng Dong, Jie Li

Abstract read
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In one paragraph

Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chen Wang *Department of Urology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Li-Jing Zhu *Department of Anesthesiology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Wei-Bo MaoDepartment of Pathology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Ting ChenDepartment of Urology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Teng-Fei GuDepartment of Urology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Sheng-Ping HuDepartment of Urology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Yong-Tao PanDepartment of Urology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Guo-Lin YanDepartment of Urology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Yun-Peng DongDepartment of Urology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China.
Jie LiDepartment of Urology, The Fifth Affiliated Hospital of Wenzhou Medical College and Lishui Municipal Central Hospital, Lishui, Zhejiang, China. lijie9783@wmu.edu.cn.

Funding

the Public welfare project of Lishui Science and Technology Bureau 2023GYX69Zhejiang Medical and Health Science Project 2023RC114
6 · The paper itself

Abstract

Biochemical recurrence (BCR) is a critical factor affecting the prognosis of prostate cancer (PCa) patients, while T cell exhaustion and metastatic prostate cancer (mPC)-related genes play significant roles in tumor progression. This study aims to identify key genes associated with BCR by integrating single-cell transcriptomics and deep learning techniques, and to validate their clinical significance. First, we identified highly expressed genes in CD8

Indexed as

Biomarkers, TumorDeep LearningErb-b2 Receptor Tyrosine KinasesProstatic NeoplasmsTranscriptomeGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleNeoplasm Recurrence, LocalPrognosisSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesBiochemical recurrenceDeep learningERBB2ImmunohistochemistryProstate cancerSingle-cell RNA sequencing

Identifiers

PMID41701406

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.