Evidence map›Paper›PMID 41701401›Full record

ArticleNeurochemical research2026

Fascin-1 Limits Secondary Damage by Preventing Oxidative‑Stress‑Induced Microglial Death After Spinal Cord Injury.

Fangjie Zhan, Dongmin Xu, Tengfei Shi, Huimin Niu, Shuiliang Wang, Eryou Feng, Yingping Cao

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fangjie Zhan *Department of Clinical Laboratory Medicine, Fuzhou Second Hospital, Fuzhou, China.
Dongmin Xu *Department of Orthopaedic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Tengfei ShiDepartment of Clinical Laboratory Medicine, Fuzhou Second Hospital, Fuzhou, China.
Huimin NiuDepartment of Clinical Laboratory Medicine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China.
Shuiliang WangDepartment of Clinical Laboratory Medicine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China.
Eryou FengDepartment of Orthopaedic Surgery, Fujian Medical University Union Hospital, Fuzhou, China. fey9001@126.com.
Yingping CaoDepartment of Clinical Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China. caoyingping@aliyun.com.

Funding

Natural Science Foundation of Fujian Province of China 2023J011552Research Fund of Fujian Medical University Union Hospital 2023XH037
6 · The paper itself

Abstract

Secondary injury after spinal cord injury (SCI) is driven by oxidative stress, microglial activation, and apoptosis. Fascin‑1, an actin‑bundling protein implicated in immune regulation, may influence these processes, but its role in SCI remains unclear. We analyzed a mouse spinal cord single‑nucleus RNA‑seq dataset across five time points after T9 SCI to define cell-type-specific Fascin‑1 dynamics. We modeled oxidative stress in human (HMC3) and mouse (BV2) microglia using H

Indexed as

Carrier ProteinsMicrofilament ProteinsMicrogliaOxidative StressSpinal Cord InjuriesAnimalsApoptosisCell DeathFemaleHumansHydrogen PeroxideMaleMiceRatsRats, Sprague-DawleyReactive Oxygen SpeciesCarrier ProteinsHydrogen PeroxideMicrofilament ProteinsReactive Oxygen SpeciesFascin-1MicrogliaOxidative stressSpinal cord injury

Identifiers

PMID41701401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.