Evidence map›Paper›PMID 41701353›Full record

ArticleJournal of neurology2026

Early serum S100β but not neuron-specific enolase reflects baseline CNS vulnerability in ICANS after CD19 CAR T-cell therapy.

Charleen Robert, Dimitri Psimaras, Sylvain Choquet, Dominique Bonnefont-Rousselot, Rana Alkouri, Mehdi Sakka, Jérôme Alexandre Denis, Clémence Marois, Caroline Houillier, Cristina Birzu and 17 more

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Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Charleen RobertSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Dimitri PsimarasSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Sylvain ChoquetSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Dominique Bonnefont-RousselotService de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpêtrière, APHP-Sorbonne Université, Paris, France.
Rana AlkouriService de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpêtrière, APHP-Sorbonne Université, Paris, France.
Mehdi SakkaService de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpêtrière, APHP-Sorbonne Université, Paris, France.
Jérôme Alexandre DenisSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Clémence MaroisSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Caroline HouillierSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Cristina BirzuSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Alice LeprinceSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Damien RicardService de Neurologie, Hôpital National d'Instruction des Armées Percy, Clamart, France.
Véronique MorelSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Madalina UzunovSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Laetitia SouchetSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Inès BoussenSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Marine BaronSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Damien Roos-WeilSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Valérie FriserSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Nathalie MirandaSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Natalia ShorSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Delphine LeclercqSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Maxens DecaveleSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Benjamin RohautSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Sophie DemeretSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Nicolas WeissSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Loïc Le GuennecSorbonne Université, AP-HP.Sorbonne Université, Faculté de Médecine, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France. loic.leguennec@yahoo.fr.ORCID http://orcid.org/0000-0001-8146-6256

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune effector cell-associated neurotoxicity syndrome (ICANS) is a frequent complication of CD19 CAR T-cell therapy. Although several biomarkers, particularly S100β, have been reported to be associated with ICANS, their biological significance and specificity remain unclear. We retrospectively studied adult patients treated with commercial CD19 CAR T cells between 2020 and 2024, focusing on early serum dynamics of S100β and neuron-specific enolase (NSE). Among 122 treated patients, 72 had complete paired biomarker measurements and were included; 21 (29%) developed ICANS at a median of 6 days after infusion. Prior CNS involvement was significantly more frequent in patients with ICANS (81% vs 35%). ΔS100β was higher in patients with ICANS compared with those without (0.03 vs 0.01 µg/L, p = 0.037), whereas ΔNSE showed no association with ICANS. In multivariable analysis, prior CNS involvement was the only independent factor associated with ICANS (OR 11.2), while ΔS100β did not retain significance. Neither biomarker correlated with ICANS severity or duration. These results indicate that early serum S100β variations mainly reflect baseline CNS vulnerability rather than ICANS-specific neurotoxicity, and that NSE provides no evidence of early neuronal injury detectable in serum.

Indexed as

Neurotoxicity SyndromesPhosphopyruvate HydrataseS100 Calcium Binding Protein beta SubunitAdultAgedAntigens, CD19BiomarkersFemaleHumansMaleMiddle AgedRetrospective StudiesT-LymphocytesAntigens, CD19BiomarkersENO2 protein, humanPhosphopyruvate HydrataseS100B protein, humanS100 Calcium Binding Protein beta SubunitBrain injury biomarkersCAR T-cell therapyCentral nervous system involvementGlial activationICANSNeuron-specific enolaseNeurotoxicityS100β

Identifiers

PMID41701353

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.