Evidence map›Paper›PMID 41701316›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Choroidal imaging biomarkers as predictors of recurrent central serous chorioretinopathy: A multicenter retrospective study - MICRoN report number five.

Arman Zarnegar, Nasiq Hasan, Sumit Randhir Singh, Adarsh Gadari, Korrina Gidwani, Elizabeth J Rossin, Charles C Wykoff, Samer Khateb, Rahul N Khurana, Zachary Kroeger and 8 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Arman ZarnegarDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nasiq HasanDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sumit Randhir SinghDepartment of Vitreoretina, Akhand Jyoti Eye Hospital, CoE Mastichak, Saran, Bihar, India.
Adarsh GadariDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Korrina GidwaniDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Elizabeth J RossinDepartment of Ophthalmology Within Massachusetts Eye and Ear (MEE), Harvard Medical School, Boston, MA, USA.
Charles C WykoffRetina Consultants of Texas, Retina Consultants of America, Houston, TX, USA.
Samer KhatebDepartment of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Rahul N KhuranaNorthern California Retina Vitreous Associates, Mountain View, California, USA.
Zachary KroegerCasey Eye Institute at Oregon Health and Science University, 515 SW Campus Dr., Portland, OR, USA.
Stela VujosevicDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Maurizio Battaglia ParodiSchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Peranut ChotcomwongseVitreoretina Unit, Department of Ophthalmology, College of Medicine, Rajavithi Hospital, Rangsit University, Bangkok, Thailand.
Paisan RuamviboonsukVitreoretina Unit, Department of Ophthalmology, College of Medicine, Rajavithi Hospital, Rangsit University, Bangkok, Thailand.
Kiran K VupparaboinaDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Lihteh WuAsociados de Macula Vitreo y Retina de Costa Rica, San José, Costa Rica.
Jay ChhablaniDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. jay.chhablani@gmail.com.ORCID http://orcid.org/0000-0003-1772-3558
Macula Society International CSCR Research Network (MICRoN)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCentral serous chorioretinopathy (CSCR) is usually self-limiting but recurs in 30-50% of cases. This study compares demographic, clinical, and imaging data between patients with and without recurrent CSCR to identify predictors of recurrence.

methodsBaseline and follow-up data were collected from 277 eyes of 265 patients with acute CSCR. Patients were divided into recurrent or non-recurrent CSCR groups based on recurrence within three months of resolution. OCT biomarkers analyzed included central macular thickness (CMT), double-layered sign (DLS), subfoveal choroidal thickness (SFCT), neurosensory retinal detachment height (NSRD), Haller layer thickness (HVT), inner choroidal thickness (ICT), and choroidal vascularity index (CVI).

resultsThis study involved 265 patients with 277 eyes. The non-recurrent group comprised 157 patients (158 eyes), with 108 (119 eyes) in the recurrent group. Baseline mean CMT and ICT at follow-up were significantly greater in the non-recurrent group than in the recurrent group. Follow-up CMT and DLS heights were significantly greater in the recurrent group. Mean CVI was significantly greater in the non-recurrent group than the recurrent group at baseline and follow-up. In a multivariate logistic regression model, hypertension was significantly negatively associated with non-recurrent CSCR (OR = 0.449, 95% CI: 0.236-0.855, p = 0.015).

conclusionThe non-recurrent group had significantly increased CMT at baseline but significantly decreased CMT and DLS height at follow-up. ICT was greater in the non-recurrent group compared to recurrent counterparts at follow-up. Mean CVI was greater in the non-recurrent group at both time points. Hypertension may be associated with disease recurrence.

Indexed as

Central Serous ChorioretinopathyChoroidFluorescein AngiographyTomography, Optical CoherenceVisual AcuityBiomarkersFemaleFollow-Up StudiesFundus OculiHumansMaleMiddle AgedRecurrenceRetrospective StudiesBiomarkersCentral serous chorioretinopathyChoroidal imaging biomarkersChoroidal vascularity indexRecurrent central serous chorioretinopathy

Identifiers

PMID41701316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.