Evidence map›Paper›PMID 41701269›Full record

ArticleJournal of hematopathology2026

A case of transient monoclonal plasma cell aberrancy following respiratory syncytial virus (RSV) vaccination.

James McHenry, Dmitrii Vozniuk, Aleksandr Romanov, Larisa Erikson, Faisal Rawas, Yaroslav Chernov, Aakash Fnu, Shukhrat A Abdukhalikov, Ariel Rischall, Kirill A Lyapichev

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Article in Journal of hematopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James McHenryDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Dmitrii VozniukDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Aleksandr RomanovDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Larisa EriksonDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Faisal RawasDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Yaroslav ChernovFirst Moscow State Medical University (Sechenov University), Moscow, Russia.
Aakash FnuDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Shukhrat A AbdukhalikovImpuls Medical Institute, Chirchiq Branch, Namangan, Uzbekistan.
Ariel RischallDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Kirill A LyapichevDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA. lyapick@ccf.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma cell neoplasms include a spectrum of disorders ranging from monoclonal gammopathy of undetermined significance to multiple myeloma, defined by clonal plasma cell proliferation and production of monoclonal immunoglobulins. However, transient monoclonal plasma cell expansions without neoplastic features are rarely documented. Herein, we report a 77-year-old female patient with a history of stage IVa high-grade serous carcinoma of the ovary who was found to have leukocytosis and 22% circulating monoclonal plasma cells during routine preoperative testing, 4 days after receiving the RSV vaccine. Flow cytometry demonstrated lambda-restricted plasma cells expressing CD19+, CD27+, CD38+, CD56-, and CD138+. Serum protein electrophoresis and immunofixation were unremarkable, with a normal κ/λ ratio and absence of M-protein. Repeat flow cytometry 6 days later revealed normalization to polyclonal plasma cells. No clinical or biochemical evidence supported a plasma cell neoplasm, and bone marrow biopsy was postponed. This case underscores the need for clinical awareness of post-vaccination immunologic phenomena that may mimic plasma cell neoplasm. Recognition of such transient aberrancies can prevent unnecessary invasive investigations and broaden understanding of vaccine-induced immune dynamics.

Indexed as

Plasma CellsVaccinationAgedFemaleHumansPlasma cell mimickersPlasma cell neoplasmRespiratory syncytial virus (RSV) vaccinationVaccination side effect

Identifiers

PMID41701269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.