Evidence map›Paper›PMID 41701118›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Runx2 Regulated Airway Homeostasis Is Disrupted in Asthma.

Junfei Wang, Alen Faiz, Qi Ge, Rob van de Velde, Theo Borghuis, Brian G Oliver, Maarten van den Berge, Victor Guryev, Alan James, John G Elliot and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Runx2 Regulated Airway Homeostasis Is Disrupted in Asthma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junfei WangDepartment of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.ORCID https://orcid.org/0009-0007-1960-5957
Alen FaizDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0003-1740-3538
Qi GeWoolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Rob van de VeldeWoolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Theo BorghuisGRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Brian G OliverWoolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-7122-9262
Maarten van den BergeDepartment of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-9336-7340
Victor GuryevUniversity of Groningen, European Research Institute for the Biology of Ageing, Groningen, University Medical Centre Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-5810-6022
Alan JamesDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.ORCID https://orcid.org/0000-0002-6018-0547
John G ElliotDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.ORCID https://orcid.org/0000-0002-4899-2948
Andrew J HalaykoUniversity of Manitoba and Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.ORCID https://orcid.org/0000-0002-7865-4552
Liang DongDepartment of Respiratory and Intensive Care Unit, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Shandong Characteristic Laboratory of Clinical Transformation of Respiratory Biological Immunity and Regenerative Medicine, Jinan, Shandong, China.ORCID https://orcid.org/0000-0001-7707-9982
Anthony W AshtonDivision of Perinatal Research, Kolling Institute of Medical Research, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-6063-1566
Janette K BurgessWoolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-9868-9966

Funding

European Union and University of GroningenMOST | National Natural Science Foundation of China (NSFC) 82000025National Health and Medical Research Council (NHMRC) #1032695National Health and Medical Research Council (NHMRC) #1061712Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) Aspasia 015.013.010
6 · The paper itself

Abstract

In asthma, augmented airway wall smooth muscle (ASM) bulk is a major remodeling feature, promoted by increased transforming growth factor (TGF)-β1 and connective tissue growth factor (CTGF). Runt-related transcription factor-2 (RUNX2) represses TGF-β1-induced CTGF through interactions with SMAD3. This study aimed to investigate the expression and role of RUNX2 in asthmatic and nonasthmatic ASM cells. mRNA and protein were detected by microarray, PCR, and western blot in nonasthmatic and asthmatic ASM cells. Immunohistochemistry identified RUNX2 in lung tissues from asthmatic patients and nonasthmatic subjects. Different RUNX2 isoforms were transfected into immortalized-asthmatic ASM cells, and markers of inflammation and airway remodeling were measured. RUNX2 alternatively spliced forms were examined in bronchial biopsies from asthmatic and healthy subjects. The abundance of RUNX2 was decreased in isolated ASM cells from asthmatic compared with nonasthmatic subjects. The ASM layer around airways in lung tissue sections from asthmatic and nonasthmatic patients had a heterogeneous pattern of RUNX2 protein detection. TGF-β1 stimulation increased RUNX2/RUNX2 variant 1 mRNA in nonasthmatic but not asthmatic ASM cells, facilitating SMAD3 activation and nuclear translocation in asthmatic ASM cells. RUNX2 isoform overexpression in immortalized asthmatic ASM cells failed to alter markers of inflammation (IL-6) but significantly reduced markers of remodeling (CTGF), ASM cell hypertrophy (GSK-3β and desmin), and proliferation (pSer

Indexed as

AsthmaCore Binding Factor Alpha 1 SubunitHomeostasisAdultAirway RemodelingCells, CulturedConnective Tissue Growth FactorFemaleHumansMaleMiddle AgedMyocytes, Smooth MuscleSmad3 ProteinTransforming Growth Factor beta1Connective Tissue Growth FactorCore Binding Factor Alpha 1 SubunitRUNX2 protein, humanSmad3 ProteinTransforming Growth Factor beta1airway remodelingairway smooth muscleasthmaRunx2Runx2 variants

Identifiers

PMID41701118
PMCPMC12911552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.