ArticleReproduction & fertility2026
An early LH surge may jeopardize ART outcomes of patients with PCOS and its predictive models.
Article in Reproduction & fertility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abstract: This study aimed to investigate whether an early LH surge during controlled ovarian stimulation (COS) affects pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART) and to explore methods for identifying high-risk patients for early intervention. In a retrospective case-control analysis of 786 PCOS cycles, an early LH surge was found to significantly increase the spontaneous abortion rate and reduce the live birth rate in in vitro fertilization and multiple embryo transfer cycles, while also correlating with a higher preterm birth rate in frozen embryo transfer cycles. Using the training set of 786 cycles, three predictive models for LH surge were developed and validated in an independent time validation set of 76 cycles. Among them, model 2 demonstrated optimal performance, with prediction feasible as early as COS day 0 and an AUC of 0.713. The findings indicate that an early LH surge may compromise ART outcomes in specific PCOS subgroups, and the proposed predictive models could aid clinicians in identifying high-risk patients and adapting treatment strategies accordingly. Lay summary: For women with polycystic ovary syndrome (PCOS) undergoing fertility treatment, a premature hormone surge can sometimes disrupt the process. Our study investigated how this early 'luteinizing hormone (LH) surge' affects pregnancy success. We found that women who experienced this early surge had more eggs collected. However, for those who had a fresh embryo transfer, it led to a higher risk of miscarriage and a lower chance of having a baby. If they used frozen embryos in a later cycle, the risk of premature birth was higher. To help patients, we also created a prediction tool. This tool uses simple information collected at the start of treatment - like a woman's body mass index and hormone levels - to identify those at high risk of this early surge. By spotting these patients early, doctors can personalize their treatment to improve their chances of a successful and healthy pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.