Evidence map›Paper›PMID 41700898›Full record

ArticleThe Analyst2026

Differences in α-synuclein conformational states in physiologically relevant pH/Na

Erick G Báez Bolívar, Jessica S Fortin, Taiwo A Ademoye, Scott A McLuckey

Abstract read
In one paragraph

Article in The Analyst, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erick G Báez BolívarDepartment of Chemistry, Purdue, University, West Lafayette, IN 47907-2084, USA. mcluckey@purdue.edul.
Jessica S FortinBasic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.ORCID http://orcid.org/0000-0002-1007-9360
Taiwo A AdemoyeBasic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Scott A McLuckeyDepartment of Chemistry, Purdue, University, West Lafayette, IN 47907-2084, USA. mcluckey@purdue.edul.ORCID http://orcid.org/0000-0002-1648-5570

Funding

Novel Ion Chemistry and Instrument Development for the Characterization of Proteins, Nucleic Acids, and Heterogeneous Bio-complexes via Tandem Mass SpectrometryR35GM153191 · NIGMS · PURDUE UNIVERSITY · PI SCOTT A MCLUCKEY · 2024 to 2026
$1.1M
Small molecule inhibitors of hyperphosphorylated tau aggregation in Alzheimer's disease: lead optimization, and proof of concept in a rodent modelK08AG071985 · NIA · PURDUE UNIVERSITY · PI Jessica Fortin · 2022 to 2026
$822k
NIA NIH HHS K08 AG071985NIGMS NIH HHS R35 GM153191
6 · The paper itself

Abstract

Native mass spectrometry implemented with theta emitters was used to demonstrate differences in conformational states of wild-type, A53T mutant, and truncated α-synuclein dissolved at physiologically relevant pH and Na

Indexed as

Acetatesalpha-SynucleinMass SpectrometrySodiumSodium ChlorideHumansHydrogen-Ion ConcentrationProtein ConformationSolutionsAcetatesalpha-Synucleinammonium acetateSodiumSodium ChlorideSolutions

Identifiers

PMID41700898
PMCPMC12911477

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.