Evidence map›Paper›PMID 41700870›Full record

ArticleAntimicrobial agents and chemotherapy2026

Elevated hippocampal and cortical cefepime concentrations correlate with seizures in an acute kidney injury rat model.

Gwendolyn M Pais, Emily Lesnicki, Sylwia Marianski, Kimberly Valdez, Zoe Gibson, Jeffri Christopher, Kathy Lepard, Annette Gilchrist, Tomoyuki Mizuno, Marc H Scheetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gwendolyn M PaisDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.ORCID 0000-0003-4961-0048
Emily LesnickiCollege of Graduate Studies, Biomedical Science Program, Midwestern University, Downers Grove, Illinois, USA.
Sylwia MarianskiCollege of Pharmacy, Doctor of Pharmacy Program, Midwestern University, Downers Grove, Illinois, USA.
Kimberly ValdezCollege of Pharmacy, Doctor of Pharmacy Program, Midwestern University, Downers Grove, Illinois, USA.
Zoe GibsonCollege of Pharmacy, Doctor of Pharmacy Program, Midwestern University, Downers Grove, Illinois, USA.
Jeffri ChristopherCollege of Pharmacy, Doctor of Pharmacy Program, Midwestern University, Downers Grove, Illinois, USA.
Kathy LepardDepartment of Biomedical Sciences, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA.
Annette GilchristCollege of Pharmacy, Pharmacometrics Center of Excellence, Midwestern University, Downers Grove, Illinois, USA.
Tomoyuki MizunoDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Marc H ScheetzDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.ORCID 0000-0002-1091-6130

Funding

Clinical Pharmacology K12 Training ProgramK12HD113190 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI TRACY A GLAUSER, Sonya C Tang Girdwood · 2023 to 2026
$1.2M
NICHD NIH HHS K12 HD113190
6 · The paper itself

Abstract

Cefepime is associated with neurotoxicity, particularly in the setting of renal impairment where drug exposure increases. This study evaluated cefepime concentrations in the brain tissue during neurotoxicity in a rat model of acute kidney injury (AKI). Male Sprague-Dawley rats (

Indexed as

Acute Kidney InjuryAnti-Bacterial AgentsCefepimeCerebral CortexHippocampusSeizuresAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyTandem Mass SpectrometryThird Generation CephalosporinsAnti-Bacterial AgentsCefepimeThird Generation Cephalosporinscefepimecortexhippocampusneurotoxicitypharmacodynamicspharmacokineticspharmacologyrattoxicodynamics

Identifiers

PMID41700870
PMCPMC13041311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.