ArticlemBio2026
Increased mutation rates and diversity are dominant features of
Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
Abstract
Multiheme cytochromes (MHCs) are the central catalysts of extracellular electron transfer and are uniquely abundant in the genomes of model Fe(III)-reducing organisms like IMPORTANCE: Dissimilatory metal-reducing bacteria are found worldwide and encode diverse multiheme cytochromes with properties suitable for applications in bioremediation, bioenergy, and bioelectronics. We find that multiheme cytochromes involved in extracellular electron transfer show poor conservation, with significantly higher mutation rates than other elements of the proteome. This previously undescribed characteristic will limit the efficacy of standard methods of homolog annotation and database mining currently used to identify specific multiheme cytochromes. Our findings also suggest that a vast pool of undiscovered multiheme cytochromes are constantly being acquired and exchanged.
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Registered trials
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