ArticleCancer biology & medicine2026
Coordinated DNA methyltransferase 3A and methyltransferase-like 7A activity reprograms the tumor microenvironment through discoidin domain receptor 1 signaling.
Article in Cancer biology & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveBreast cancer is the most common malignancy in women and is characterized by a high recurrence rate that severely impacts patient survival. Regulatory T cells (Tregs) in the tumor microenvironment (TME) promote immune evasion and metastasis, increasing recurrence risk. This study determined how the epigenetic regulators, DNMT3A and METTL7A, modulate Treg infiltration
methodsRNA sequencing (RNA-seq) was used to identify differentially expressed genes (DEGs), followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. Machine learning algorithms, including least absolute shrinkage and selection operator (LASSO), supported vector machine-recursive feature elimination (SVM-RFE) and ElasticNet identified DDR1 as a key gene. Validation included RT-qPCR, western blot, MSP, MeRIP-qPCR, and Co-IP to assess epigenetic regulation. Functional assays (CCK-8, Transwell, and Treg differentiation/chemotaxis) and xenograft models evaluated the role of
resultsDNMT3A upregulated
conclusionsDNMT3A and METTL7A were shown to cooperatively regulate
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