Evidence map›Paper›PMID 41700543›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Development of a Novel Polyleucine-Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus.

Lantian Lu, Jazmina L Gonzalez Cruz, Rabina Giri, Yuexiao Zhang, Sahra Bashiri, Leslie C Domínguez Cadena, Shuhang Li, Zeinab G Khalil, Waleed M Hussein, Jingwen Wang and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Lantian LuSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-7006-4339
Jazmina L Gonzalez CruzFrazer Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Rabina GiriMater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Yuexiao ZhangSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Sahra BashiriSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Leslie C Domínguez CadenaFrazer Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Shuhang LiMater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Zeinab G KhalilAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Waleed M HusseinInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Jingwen WangSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Jolynn KiongAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Xuehan LuFrazer Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Jiahui ZhangSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Miao LuSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Wenbin HuangSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Wei Yang KongFrazer Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Ummey Jannatun NaharSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Prashamsa KoiralaSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Zhong GuoSchool of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland, Australia.
Patricia WaldenSchool of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland, Australia.
Antje BlumenthalFrazer Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Jakob BegunMater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Kirill AlexandrovSchool of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland, Australia.
Istvan TothSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Rachel J StephensonSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Mariusz SkwarczynskiSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0001-7257-807X

Funding

ARC Centres of Excellence in Synthetic Biology CE200100029National Health and Medical Research Council APP2028090
6 · The paper itself

Abstract

Mixture-based vaccine formulations offer distinct advantages by eliminating the need for chemical conjugation or complex encapsulations, thereby streamlining preparation, enhancing versatility, and reducing cost and production time. In this study, we report the design of a novel polypeptide-based self-assembling adjuvant where a water insoluble 15-mer polyleucine (L

Indexed as

Adjuvants, ImmunologicPeptidesStreptococcus pyogenesVaccines, SubunitAnimalsDendritic CellsProtein Subunit VaccinesAdjuvants, ImmunologicPeptidespolyleucineProtein Subunit VaccinesVaccines, Subunitadjuvant discoverygroup A streptococcuspolyleucinesubunit vaccinesvaccine immunopotentiators

Identifiers

PMID41700543
PMCPMC13089101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.