Evidence map›Paper›PMID 41700342›Full record

ArticleFuture science OA2026

Soluble cytokine receptor levels in obstructive sleep apnea patients treated with continuous positive airway pressure therapy.

Sarah Hall Kiriluk, Lisa A Freeburg, Samira Khan, Cameron S McAlpine, Oren Cohen, Vaishnavi Kundel, Mayte Saurez-Farinas, Francis G Spinale, Neomi Shah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah Hall KirilukCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA.ORCID 0000-0002-4026-3118
Lisa A FreeburgCell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA.
Samira KhanDivision of Pulmonary, Sleep, and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cameron S McAlpineDepartment of Medicine, Cardiovascular Research Institute, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Oren CohenDivision of Pulmonary, Sleep, and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Vaishnavi KundelDivision of Pulmonary, Sleep, and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mayte Saurez-FarinasDivision of Pulmonary, Sleep, and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francis G SpinaleDivision of Pulmonary, Sleep, and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neomi ShahDivision of Pulmonary, Sleep, and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Imaging the Atherosclerosis Cascade in Sleep ApneaR01HL143221 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHAH, NEOMI A · 2018 to 2022
$4.2M
Therapeutic Targeting of Tissue Inhibitor-4 in Hypertrophy and FailureR01HL130972 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SPINALE, FRANCIS G · 2016 to 2019
$1.9M
Multidisciplinary Research Training in Sleep ScienceT32HL160511 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI INDU A AYAPPA, ANDREW W VARGA · 2023 to 2026
$1.5M
Use of Novel Multi-modality Imaging to Evaluate the Relationship Between Sleep Duration, Vascular Inflammation, and Visceral AdiposityK23HL161324 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Vaishnavi Kundel · 2022 to 2026
$956k
BLRD VA I01 BX000168BLRD VA I01 BX005320NHLBI NIH HHS K23 HL161324NHLBI NIH HHS R01 HL130972NHLBI NIH HHS R01 HL143221NHLBI NIH HHS T32 HL160511
6 · The paper itself

Abstract

aimsContinuous positive airway pressure (CPAP) is an established therapy for obstructive sleep apnea (OSA), but how CPAP compliance changes inflammation/cytokine activation remains unclear. MATERIALS AND

methodsPlasma from patients with OSA (

resultsWith OSA, plasma levels of sCD30, sEGFR, sIL1RII, and sVEGFR2 increased by over 2-fold (

conclusionsThese results identified that a specific set of soluble cytokine receptors, including sCD30, sEGFR, sIL1RII, and sVEGFR2, may serve as indices of cytokine activation in patients with OSA and also identify therapeutic response such as CPAP.

Indexed as

airway therapycardiovascular diseasecomplianceCPAPInflammationobstructive Sleep apneaOSAsoluble biomarkers

Identifiers

PMID41700342
PMCPMC12915782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.