Evidence map›Paper›PMID 41700228›Full record

ArticleCureus2026

Comorbidity and Procedural Factors Associated With Auditory Brainstem Response Outcomes in Children Under Anesthesia.

Christina Zhu, Henna Tiwary, Ashwini M Tilak, Sophia I Jaguan, Hengameh Behzadpour, Susan Verghese, Tracey Ambrose, Diego Preciado, Brian K Reilly

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christina ZhuOtolaryngology - Head and Neck Surgery, Georgetown University School of Medicine, Washington, D.C., USA.
Henna TiwaryOtolaryngology - Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.
Ashwini M TilakOtolaryngology - Head and Neck Surgery, Children's National Hospital, Washington, D.C., USA.
Sophia I JaguanOtolaryngology - Head and Neck Surgery, University of Miami School of Medicine, Miami, USA.
Hengameh BehzadpourOtolaryngology - Head and Neck Surgery, Children's National Hospital, Washington, D.C., USA.
Susan VergheseAnesthesiology, Children's National Hospital, Washington, D.C., USA.
Tracey AmbroseHearing and Speech, Children's National Hospital, Washington, D.C., USA.
Diego PreciadoOtolaryngology - Head and Neck Surgery, Children's National Hospital, Washington, D.C., USA.
Brian K ReillyOtolaryngology, Children's National Hospital, Washington, D.C., USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction We aim to evaluate the influence of patient comorbidities and procedural context (standalone vs. combined procedures) on auditory brainstem response (ABR) outcomes in children and to explore whether anesthesia type (propofol vs. sevoflurane) contributes to differences in hearing thresholds. Methods A retrospective chart review was conducted of 403 pediatric patients who underwent sedated ABR testing between October 2020 and 2023 at a tertiary children's hospital. Demographic, anesthetic, and clinical variables, including neurological, cardiac, and respiratory comorbidities, were analyzed. Hearing outcomes were categorized as normal versus any hearing loss across click and tone-burst frequencies. Logistic regression analyses examined associations between hearing loss, anesthesia type, comorbidities, and procedural context, adjusting for American Society of Anesthesiologists (ASA) classification. Results No significant association was found between anesthesia type and ABR thresholds after adjusting for ASA class. In contrast, children with cardiac (36% vs. 53%; p=0.008) or respiratory (40% vs. 57%; p=0.013) comorbidities were significantly more likely to exhibit hearing loss. Patients undergoing combined procedures were more likely to have normal hearing than those having standalone ABR testing (69% vs. 60%; p=0.006). Neurological comorbidities showed no significant association. Conclusion Comorbidities, particularly cardiac and respiratory conditions, and procedural context were stronger predictors of ABR outcomes than anesthesia type. These findings suggest anesthetic choice may not independently alter ABR thresholds, emphasizing the importance of considering patient health status and procedural setting when interpreting pediatric ABR results.

Indexed as

auditory brainstem responsesmedical comorbiditiespediatric anesthesiapediatric hearing losssevoflurane vs propofol

Identifiers

PMID41700228
PMCPMC12906905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.