ArticleCureus2026
External Validation of the Simplified Acute Physiology Score-3 in a Cohort of 5,033 Patients in Mexico.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
backgroundSince its introduction, the Simplified Acute Physiology Score-3 (SAPS-3) has remained one of the most widely adopted scoring systems for mortality prediction in critically ill patients. This study aims to assess the performance of the SAPS-3 in a contemporary cohort of intensive care unit (ICU) patients in Mexico. METHODOLOGY: Data were obtained from a prospective database, covering admissions from September 2009 to May 2024. We evaluated the discriminative ability and calibration of SAPS-3 for mortality prediction using the area under the receiver operating characteristic curve (AUC) and the Hosmer-Lemeshow goodness-of-fit test. This study adhered to the guidelines for transparent reporting of multivariable prediction models for individual prognosis or diagnosis (TRIPOD).
resultsA total of 5,033 patients were included, with a mean age of 63 ± 18 years. In-hospital mortality was 1,211 (24.06%). The SAPS-3 score had a mean of 54 ± 19, corresponding to an estimated mortality of 1,560 (31.0%). For the entire cohort, the SAPS-3 demonstrated an AUC of 0.801 (95% confidence interval (CI), 0.787-0.815), and χ
conclusionsValidation studies of SAPS-3 across diverse ICU populations consistently report good discriminative ability but limited calibration. This is the first study in Mexico with a large ICU sample, affirming that while SAPS-3 provides reliable discrimination, it tends to overestimate mortality risk.
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