ArticleWorld journal of clinical cases2026
Clinical outcomes of multidrug-resistant organism infections in a tertiary care hospital in India.
Article in World journal of clinical cases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Hospital Cost Components and Predictors inTropical medicine and infectious disease · 2026Article
- Risk Factors and Medical Burden of Multidrug-Resistant Organism Infection in Hospitalized Patients with Pneumonia.Infection and drug resistance · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundMultidrug-resistant organisms (MDROs) pose a major threat to hospital care, with antimicrobial resistance contributing to an estimated 4.95 million deaths globally in 2019 (including 1.27 million directly attributable deaths). India carries a particularly high burden.
aimTo evaluate clinical outcomes associated with MDRO isolation in a tertiary-care center and identifies actionable signals to strengthen infection prevention and targeted antimicrobial stewardship.
methodsWe conducted a cross-sectional analysis of culture-confirmed MDRO infections treated as pathogens at All India Institute of Medical Sciences Rishikesh from May 2021 to November 2024 using E-Hospital records. Incomplete datasets were excluded. Associations between isolation practices and clinical outcomes-including mortality, length of stay (LOS), and intensive care unit (ICU) utilization-were assessed using
resultsA total of 1598 MDRO infected patients were included (mean age 42.8 years; 58.5% male). Overall mortality was 20.8%. ICU care was required in 439 patients (27.5%), and 29.2% had at least one comorbidity. Among ICU patients, 143 (32.6%) were isolated and 296 (67.4%) were not. Mortality did not differ significantly between isolated (46%) and non-isolated (54%) groups (
conclusionMDRO infections are associated with substantial mortality and prolonged ICU and hospital stays. Marked interdepartmental variability in antibiotic use highlights the need for strengthened infection-prevention practices and targeted antimicrobial stewardship, including de-escalation, intravenous-to-oral switching, and optimized treatment durations to reduce selection pressure. Limited culture availability during 2022 was a key constraint. The associations observed between isolation status and clinical outcomes further highlight the importance of reinforcing infection-control strategies and stewardship efforts in high-risk departments.
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