Evidence map›Paper›PMID 41700170›Full record

ArticleWorld journal of gastrointestinal endoscopy2026

Altered endocannabinoid system gene expression in inflammatory bowel disease mucosa: New perspectives in inflammatory bowel disease management.

Iulia Andreea Pelisenco, Alessandro Salvi, Giuseppina De Petro, Ioana Andreea Musat, Teodora Ecaterina Manuc, Cristian George Tieranu, Gabriel Becheanu, Elena Milanesi, Maria Dobre

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In one paragraph

Article in World journal of gastrointestinal endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Iulia Andreea PelisencoDepartment of Pathology, Victor Babes National Institute of Pathology, Bucharest 050096, Romania.
Alessandro SalviDivision of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Lombardy, Italy.
Giuseppina De PetroDivision of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Lombardy, Italy.
Ioana Andreea MusatFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania.
Teodora Ecaterina ManucFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania.
Cristian George TieranuGastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania.
Gabriel BecheanuFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania.
Elena MilanesiDepartment of Pathology, Victor Babes National Institute of Pathology, Bucharest 050096, Romania.
Maria DobreDepartment of Pathology, Victor Babes National Institute of Pathology, Bucharest 050096, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory bowel disease (IBD) is a broad classification including various chronic inflammatory gastrointestinal conditions that comprises two main disorders: Crohn's disease (CD) and ulcerative colitis (UC). The key components of the endocannabinoid system (ECS) are highly expressed within the gastrointestinal tract, playing a crucial role in maintaining homeostasis and providing protection against intestinal inflammation.

aimTo investigate possible impairment of the genes belonging to ECS by analyzing their expression levels in IBD patients and controls.

methodsThe paired biopsies of endoscopically inflamed (IM) and noninflamed (NIM) colonic mucosa from 30 IBD-diagnosed patients (17 UC and 13 CD), and the colonic mucosa from 17 non-IBD controls, were collected and analyzed. The messenger RNA expression level of cannabinoid receptor (CNR) 1,

resultsSix out of the 10 investigated genes were found to be dysregulated in at least one comparison. Specifically, in IBD patients, FAAH, PPARG, and TRPV1 were significantly downregulated in IM compared to NIM (FAAH,

conclusionWe found a significant impairment of the ECS in IBD patients. Further analyses on larger cohorts are needed for a better understanding of the potential of cannabinoids in managing IBD.

Indexed as

Crohn’s diseaseEndocannabinoid systemGene expressionInflammatory bowel diseaseUlcerative colitis

Identifiers

PMID41700170
PMCPMC12906222

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