Evidence map›Paper›PMID 41700134›Full record

ArticlePeerJ2026

Multiomics analysis of polyamine metabolism in colorectal cancer, highlighting the key role of extracellular putrescine in impairing CXCR6

Ziru Tan, Yuqiang Zhang, Cong Pei Jia, Haifeng Lian, Bin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ziru Tan *Department of Gastroenterology and Institute of Digestive Disease, Binzhou Medical University Hospital, Binzhou, China.
Yuqiang Zhang *Yantai Affiliated Hospital of Binzhou Medical University, Department of Clinical Laboratory, Yantai, China.
Cong Pei JiaDepartment of Gastroenterology and Institute of Digestive Disease, Binzhou Medical University Hospital, Binzhou, China.
Haifeng LianDepartment of Gastroenterology and Institute of Digestive Disease, Binzhou Medical University Hospital, Binzhou, China.
Bin WangDepartment of Gastroenterology and Institute of Digestive Disease, Binzhou Medical University Hospital, Binzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contribution of putrescine (PUT) metabolism to impaired tumor immunosurveillance in colorectal cancer (CRC) requires a thorough examination of its biosynthesis, catabolism, and transport during tumor development. This study found, unexpectedly, that a better prognosis was associated with higher expression of the PUT biosynthesis genes

Indexed as

CD8-Positive T-LymphocytesColorectal NeoplasmsPolyaminesPutrescineReceptors, ChemokineCell Line, TumorCell ProliferationFemaleHumansMalePrognosisReceptors, CXCR6CXCR6 protein, humanPolyaminesPutrescineReceptors, ChemokineReceptors, CXCR6Colorectal cancerCXCR6+CD8+ T cellsCytotoxic activityODC1Putrescine metabolisms

Identifiers

PMID41700134
PMCPMC12906710

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.