ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Factors impacting survival in individuals with Down syndrome-associated Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Death in People with Down syndrome: Mortality statistics and novel predictors in US Medicaid and Medicare enrolled adults.medRxiv : the preprint server for health sciences · 2026Article
- Factors impacting survival in individuals with Down syndrome-associated Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
introductionAdults with Down syndrome (DS) are at high risk for Alzheimer's disease (AD), the leading cause of death in this population. Survival in DS after AD diagnosis appears shorter than in sporadic AD; however, the factors influencing survival remain poorly understood.
methodsWe analyzed 157 adults with DS from Spain and Ireland who died of AD between 2012 and 2024. Clinical, genetic, and care predictors were examined using Kaplan-Meier curves and Cox regression.
resultsMean survival after AD diagnosis was 4.8 years (SD 3.5). Those in specialist intellectual disability dementia care had a longer survival time (mean 9.5 years) than other settings (mean 3.4 to 4.1 years; p < 0.001). Late-onset myoclonic epilepsy in DS (LOMEDS) was linked to a threefold higher risk of death after onset (p < 0.001). DISCUSSION: Specialist care settings and LOMEDS timing significantly shape survival in DS-associated AD, highlighting the importance of tailored services and proactive epilepsy treatment.
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