Evidence map›Paper›PMID 41699982›Full record

ReviewBioconjugate chemistry2026

Molecular Design Strategies Enabling Activity-Based Sensing and Labeling as a Platform for Probing Enzyme Activity, Redox Regulation, and Transition-Metal Signaling.

Hanna I Humpel, Alexander P Luancing, Benjamin H Shostak, Marco S Messina

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hanna I HumpelDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0009-0009-4442-0748
Alexander P LuancingDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0009-0002-5937-9492
Benjamin H ShostakDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0009-0001-4679-3814
Marco S MessinaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0003-2827-118X

Funding

Watson Phase I COBRE Research CoreP20GM156674 · NIGMS · UNIVERSITY OF DELAWARE · PI Donald Allen Watson · 2025 to 2026
$7.5M
An Activity-Based Biomolecule Labeling Platform for the Imaging of Cells and Tissues Under Oxidative StressR00GM143573 · NIGMS · UNIVERSITY OF DELAWARE · PI MESSINA, MARCO · 2023 to 2025
$729k
NIGMS NIH HHS P20 GM156674NIGMS NIH HHS R00 GM143573
6 · The paper itself

Abstract

Activity-based sensing and labeling (ABSL) has emerged as a powerful platform for the selective detection of transient biological analytes with high sensitivity and spatial fidelity. Here, we highlight emerging molecular design strategies that leverage ABSL for advanced investigations of critical cellular signaling processes. We summarize key biological insights resulting from ABSL of enzyme activity, reactive oxygen and nitrogen species (ROS/RNS), and labile transition-metal pools.

Indexed as

Biosensing TechniquesEnzymesSignal TransductionTransition ElementsAnimalsHumansOxidation-ReductionReactive Nitrogen SpeciesReactive Oxygen SpeciesEnzymesReactive Nitrogen SpeciesReactive Oxygen SpeciesTransition Elements

Identifiers

PMID41699982
PMCPMC12944542

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.