Evidence map›Paper›PMID 41699949›Full record

ArticleBipolar disorders2026

Understanding the Current State of Play of Early Intervention for Bipolar Disorder: Qualitative Analysis of Consultations With International Stakeholders.

Sue M Cotton, Vani Jain, Aswin Ratheesh, Clare Shelton, Craig Macneil, Kate M Filia, Jacob Crouse, Annabel Burnside, Emily Clarke, Alesha Prasad and 3 more

Abstract read
In one paragraph

Article in Bipolar disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sue M CottonSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-9386-8348
Vani JainDaymark Foundation, Toronto, Ontario, Canada.
Aswin RatheeshSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Clare SheltonSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Craig MacneilSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Kate M FiliaSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Jacob CrouseBrain and Mind Centre, University of Sydney, Camperdown, New South Wales, Australia.
Annabel BurnsideSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Emily ClarkeSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Alesha PrasadSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Rosie ArnoldSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Paul BadcockSchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Melissa HastySchool of Psychological Sciences, Monash University, Clayton, Victoria, Australia.

Funding

Daymark Foundation
6 · The paper itself

Abstract

backgroundDespite the burden associated with bipolar disorder (BD), research into early diagnosis and treatment of BD lags approximately 20 years behind the field of early intervention for psychosis. This study evolved through a partnership between Orygen (Melbourne, Australia) and the Daymark Foundation (Toronto, Canada). The primary focus was to answer the question: "How might we advance an early intervention approach for people at-risk of or with BD?".

methodsSemi-structured interviews were conducted with international experts and other stakeholders in early intervention and BD to identify challenges and barriers in early intervention approaches to BD.

resultsTwenty-eight experts participated. Nine themes emerged as challenges: (i) limited recognition and understanding of BD across stakeholders; (ii) lack of definitions; (iii) poor resourcing and lack of prioritisation in funding models; (iv) absence of validated tools for diagnosis, monitoring treatment response and/or disorder progression; (v) absence of "big data"; (vi) scarcity of evidence-based treatments and clinical guidelines for the early stages of the disorder; (vii) obscurity around optimal service models; (viii) the need for better support and involvement of families and significant others; and (ix) the need for collaboration (across disciplines, stakeholders, and settings) to progress the field. LIMITATIONS: Of those approached, 54.9% participated in the study. Given the qualitative nature of the study, recruiting more experts to the study would not necessarily change the outcomes as data saturation was achieved.

conclusionsThis work lays the foundations for developing a collaborative research framework to progress early intervention for young people with BD.

Indexed as

Bipolar DisorderEarly Medical InterventionStakeholder ParticipationEarly DiagnosisHumansQualitative Researchat‐riskbig databipolar disordercommunity awarenessearly interventioneducationfamiliesoutcome measurementservice modelstreatment

Identifiers

PMID41699949
PMCPMC12910188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.