Evidence map›Paper›PMID 41699871›Full record

ArticleBrain and behavior2026

Visual-Vestibular Modification of Egomotion Perception in Patients With Persistent Postural-Perceptual Dizziness in Supine and Standing Positions.

Skadi Gerkensmeier, Hannah Keller, Pia Herborn, Renana Storm, Christoph Helmchen, Andreas Sprenger

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Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Skadi GerkensmeierDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.
Hannah KellerDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.
Pia HerbornDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.
Renana StormDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.ORCID https://orcid.org/0009-0007-8111-6281
Christoph HelmchenDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.
Andreas SprengerDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.

Funding

Deutsche Forschungsgemeinschaft HE 2689/6-1German Research Foundation HE 2689/6-1
6 · The paper itself

Abstract

backgroundPersistent postural-perceptual dizziness (PPPD) has been classified by the Bárány Society as a chronic functional dizziness disorder with perceived unsteadiness. Symptoms typically worsen by upright posture or exposure to moving visual stimuli or complex visual patterns. The specific visual features remain poorly defined. We investigated how visual, vestibular, and combined visual-vestibular stimulation affects egomotion perception in PPPD patients, comparing responses in upright and supine positions to those of age-matched healthy controls (HC).

methodsParticipants performed a self-rating of perceived egomotion in two sessions with two different body positions: supine and upright standing. During both sessions, participants were exposed to three types of visual stimulation designed to differ by the degree of elicited egomotion: a black-and-white silent movie, a flow field animation, and a rollercoaster video from the driver's perspective. Each visual stimulus was presented in combination with one of three binaural vestibular galvanic stimulation conditions (GVS): no stimulation (noGVS), fixed intensity stimulation (fixGVS: 1.3 mA), or sham (sham: 1.3 mA).

resultsPPPD patients consistently reported stronger egomotion than HC, regardless of the stimulation condition. Both visual and vestibular inputs robustly influenced egomotion perception in standing and supine positions. Egomotion perception of PPPD patients in the standing, compared to the supine position, was larger during rollercoaster stimulation.

conclusionOur findings challenge the notion of generalized visual hypersensitivity in PPPD. They rather point to a context-dependent alteration of egomotion perception during upright stance. Differences disappear with concomitant vestibular stimulation supporting the need for vestibular rehabilitation in PPPD.

Indexed as

DizzinessMotion PerceptionPersistent Postural-Perceptual DizzinessVestibule, LabyrinthVisual PerceptionAdultAgedFemaleHumansMaleMiddle AgedPhotic StimulationPostural BalancePostureStanding PositionSupine Positionbody positionegomotion perceptionpersistent perceptual postural dizzinessvestibularvisual stimulation

Identifiers

PMID41699871
PMCPMC12910126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.