ArticleJournal of applied clinical medical physics2026
In-Silico Trial of Same-Day Simulation-Free Spatially Fractionated Adaptive Radiotherapy (SF
Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- In-Silico Trial of Same-Day Simulation-Free Spatially Fractionated Adaptive Radiotherapy (SFJournal of applied clinical medical physics · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
purposeHere we present an in-silico trial of the feasibility and deliverability of a same-day, simulation-free workflow for spatially fractionated adaptive radiotherapy (SF METHODS AND MATERIALS: Ten patients (five thoracic and five extremity), previously treated with spatially fractionated radiotherapy (SFRT), were selected for this in silico trial. A two-phase regimen was simulated: Phase 1 delivered 12 Gy SBRT to a uniform, predefined high-dose lattice and 4 Gy to the gross tumor volume (GTV); Phase 2 consisted of 4 additional fractions of 4 Gy to the GTV. The planning workflow was performed entirely in silico, without the need for CT simulation. High-dose sphere matrices were generated with a custom script and aligned to physician-defined GTVs. Adaptive plans were created based on CBCT anatomy and evaluated for dosimetric quality, deliverability, and workflow timing. Comparisons were made to the original clinically delivered plans. Mobius3D was used for secondary dose verification.
resultsAll 10 cases were successfully replanned using the SF
conclusionsThis in-silico study demonstrates the feasibility of delivering spatially fractionated SBRT without simulation CT using a same-day adaptive workflow. The SF
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.