Evidence map›Paper›PMID 41699743›Full record

ArticleBMC research notes2026

Comparative analysis of four sequencing platforms for methylation sequencing.

Jinxia Guan, Chuanchun Yang, Hongjun Gao, Shuanping Liu, Min Zheng, Yongjun Li, Baochen Du, Changling Zhang, Yuanyuan Guo, Qi Wang and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jinxia Guan *BioChain(Beijing) Science & Technology, Inc., Beijing, 102600, China.
Chuanchun Yang *Shanghai Salus Life Sciences Co., Ltd., 4 Floor, Building 6, No. 830 Chengyin Road, Dachang Town, Baoshan District, Shanghai, China.
Hongjun Gao *Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030013, China.
Shuanping LiuBioChain(Beijing) Science & Technology, Inc., Beijing, 102600, China.
Min ZhengRespiratory and Critical Care Medicine, Emergency General Hospital & National Research Center for Emergency Medicine, Beijing, China.
Yongjun LiBioChain(Beijing) Science & Technology, Inc., Beijing, 102600, China.
Baochen DuBioChain(Beijing) Science & Technology, Inc., Beijing, 102600, China.
Changling ZhangShanghai Salus Life Sciences Co., Ltd., 4 Floor, Building 6, No. 830 Chengyin Road, Dachang Town, Baoshan District, Shanghai, China.
Yuanyuan GuoBioChain(Beijing) Science & Technology, Inc., Beijing, 102600, China.
Qi WangShanghai Salus Life Sciences Co., Ltd., 4 Floor, Building 6, No. 830 Chengyin Road, Dachang Town, Baoshan District, Shanghai, China.
Luyang ZhaoShanghai Salus Life Sciences Co., Ltd., 4 Floor, Building 6, No. 830 Chengyin Road, Dachang Town, Baoshan District, Shanghai, China. lzhao@salus-bio.com.
XiaoLiang HanBioChain(Beijing) Science & Technology, Inc., Beijing, 102600, China. sean.han@biochainbj.com.

Funding

National Key Science and Technology Major Project (for Deep Earth Research), Deep subsurface microbial dynamic evolution and knowledge graph visualization 2024ZD1000603
6 · The paper itself

Abstract

This study conducts a comprehensive assessment of four sequencing platforms: GenoLab M (Genemind), NovaSeq X (Illumina), T7 (MGI) and Salus Pro (Salus), focusing on different performance metrics related to methylation data. By analyzing data from plasma cfDNA samples, we assessed key metrics including sequencing quality, CpG coverage, data efficiency, and methylation level consistency. These findings aim to provide valuable insights into the consistency of sequencing platforms for researchers and laboratories when integrating multiple methylation datasets for analysis.

Indexed as

DNA MethylationHigh-Throughput Nucleotide SequencingSequence Analysis, DNACpG IslandsHumansCpGDNA methylationMultiple sequencing platforms

Identifiers

PMID41699743
PMCPMC13015060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.