Evidence map›Paper›PMID 41699727›Full record

SynthesisSystematic reviews2026

The prevalence of panic disorder in chronic obstructive pulmonary disease: a systematic review, meta-analysis, and meta-regression.

Bronwyn Todd, Guillaume Foldes-Busque, Kimberley L Way, Khang Duy Ricky Le, Marlies Alvarenga, Christopher M Celano, Jeff C Huffman, Phillip J Tully

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Systematic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bronwyn ToddSchool of Psychology, La Trobe University, Flora Hill, Bendigo, VIC, Australia.
Guillaume Foldes-BusqueSchool of Psychology, Université Laval Québec, Quebec, Canada.
Kimberley L WayInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.
Khang Duy Ricky LeSchool of Medicine, Faculty of Health, Deakin University, Geelong, Victoria, Australia.
Marlies AlvarengaInstitute of Health and Wellbeing, Federation University Australia, Berwick, Victoria, Australia.
Christopher M CelanoDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Jeff C HuffmanDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Phillip J TullySchool of Psychology, Deakin University, Geelong, Victoria, 3216, Australia. p.tully@deakin.edu.au.ORCID 0000-0003-2807-1313

Funding

A novel behavioral intervention to promote adherence in heart failureR01HL155301 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CELANO, CHRISTOPHER M · 2021 to 2025
$3.8M
NHLBI NIH HHS R01 HL155301
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) symptoms of dyspnea and chest tightness overlap with some symptoms of panic attacks, the hallmark feature of panic disorder (PD). Our objective was to quantify PD prevalence in COPD from a systematic review and meta-analysis.

methodsA database search from inception to January 2025 was performed using five electronic databases. Eligible studies utilized structured clinical psychiatric interviews to identify PD in adult populations with COPD derived from inpatient, outpatient, or general population sampling.

resultsTwenty-one studies met inclusion criteria, with most from Asia (k = 9), reporting data from 1847 persons with COPD, 860 healthy controls, and 450 persons with comorbidities other than COPD. The prevalence of PD in persons with COPD was 12.5% (95% confidence interval [CI] 8.2-18.7, I

conclusionsThe pooled estimates of PD in COPD were higher than the general population but markedly lower than suggested by prior narrative reviews. Further research needs to elucidate whether the characteristic symptoms of panic in COPD are similar to PD in non-COPD populations and, secondly, whether they lead to differential healthcare resource utilization and portend a higher risk for adverse outcomes. SYSTEMATIC REVIEW REGISTRATION: CRD42024559743.

Indexed as

Panic DisorderPulmonary Disease, Chronic ObstructiveComorbidityHumansPrevalenceChronic obstructive airway diseaseChronic obstructive pulmonary diseaseMeta-analysisPanic attackPanic disorder

Identifiers

PMID41699727
PMCPMC13014743

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.