ArticleJournal of anesthesia, analgesia and critical care2026
Effect of norepinephrine on ventricular systolic function during septic shock: the ENESySS study.
Article in Journal of anesthesia, analgesia and critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hour-1 Sepsis Bundle: Updated Evidence.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine whether norepinephrine improves the left ventricle systolic function in early septic shock patients.
methodsSingle-center, prospective, observational study in critically ill patients over a 2-year period in Italy. Hypotensive patients were included within 24 hours from the diagnosis of septic shock; preload responsiveness was excluded by a passive leg raising test. The main objective was the augmentation of the left ventricular outflow tract velocity time integral (LVOT-VTI) induced by the increase of norepinephrine infusion dosage.
resultsThirty patients were included in the final analysis, with a median age and SAPS II score of 67 (51-77) years and 49 (41-65), respectively. All patients were mechanically ventilated, 25 (83%) invasively and 5 (17%) non-invasively. The time elapsed between septic shock diagnosis and inclusion was 8 (3-17) hours. The norepinephrine infusion dose was increased from 0.3 (0.2-0.6) to 0.6 (0.4-0.9) µg kg
conclusionsNorepinephrine improved the left ventricle systolic function and the ventriculoarterial coupling in septic shock patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.