Evidence map›Paper›PMID 41699682›Full record

ArticleVirology journal2026

Mapping the global research landscape on HPV vaccine hesitancy: a machine-learning based bibliometric analysis.

Jialao Ma, Peiyan Deng, Bowen Lin, Pincheng Luo, Wei Wu, Sijia Liu

Abstract read
In one paragraph

Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jialao MaShenzhen Luohu District Center for Disease Control and Prevention, Shenzhen, China.
Peiyan DengSchool of Public Health, Guangzhou Medical University, Guangzhou, China.
Bowen LinFujian Provincial Department of Natural Resources, Fuzhou, China.
Pincheng LuoSchool of Medicine, University of Galway, Galway, Ireland.
Wei Wu *Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, China. wuwei2005@126.com.
Sijia Liu *School of Law and Intellectual Property, Guangdong Polytechnic Normal University, Guangzhou, China. liusijiaruc@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHPV vaccination remains the most effective strategy for cervical cancer prevention, yet hesitancy impedes global uptake. Given the rapidly expanding and fragmented literature, traditional reviews struggle to capture dynamic thematic shifts. This study utilized a machine-learning-enhanced bibliometric approach to map the knowledge domain and identify evolutionary trends in HPV vaccine hesitancy research.

methodsWe analyzed publications retrieved from the Web of Science Core Collection (WoSCC) between 2011 and 2025. VOSviewer, CiteSpace, and Bibliometrix were employed to construct co-authorship and citation networks. Furthermore, we applied Latent Dirichlet Allocation (LDA), a probabilistic topic modeling algorithm, to conduct an unsupervised analysis of abstract texts, enabling the detection of latent semantic themes and their temporal evolution.

resultsA total of 711 publications were identified, showing an exponential growth trajectory since 2017. The United States contributed over half of the global output (53.4%), revealing a geographical imbalance compared to low- and middle-income countries (LMICs). LDA modeling unveiled three distinct thematic clusters: (1) determinants of adolescent vaccination and parental decision-making; (2) public health strategies for improving uptake and knowledge; and (3) the disrupting impact of social media and COVID-19-related misinformation. While early research focused on “access” and “safety”, post-2020 topics have heavily shifted towards “infodemics” and “trust”.

conclusionThe research landscape on HPV vaccine hesitancy was characterized by significant geographic disparities, with high-income countries dominating the discourse despite the higher disease burden in LMICs. The application of LDA revealed a stagnation in traditional barrier studies and a critical pivot towards digital information ecosystems. These findings highlighted a disconnect between scholarly output and practical vaccination coverage, underscoring the need for research to pivot from descriptive surveys to intervention-based studies in underrepresented regions.

Indexed as

BibliometricsMachine LearningPapillomavirus InfectionsPapillomavirus VaccinesVaccination HesitancyFemaleHuman Papillomavirus VirusesHumansUterine Cervical NeoplasmsVaccinationPapillomavirus VaccinesBibliometric analysisGlobal researchHPVLatent dirichlet allocation (LDA)Public healthScientometricsVaccine hesitancy

Identifiers

PMID41699682
PMCPMC13014958

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.