SynthesisBMC oral health2026
Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and pain perception in human studies: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
introductionLow-intensity pulsed ultrasound (LIPUS) has been proposed as a non-invasive adjunct to accelerate orthodontic tooth movement (OTM) and reduce treatment-related pain, but findings remain inconsistent. This systematic review and meta-analysis aimed to evaluate its clinical effectiveness.
methodThis systematic review and meta-analysis followed PRISMA 2020. Comprehensive literature searches were conducted in PubMed, Embase, Scopus, Cochrane Library, and Web of Science, covering all records available up to May 25, 2025. Eligible human studies were assessed for risk of bias and data were systematically extracted. All included studies were synthesized qualitatively, while pain outcomes at 24 h from four studies were pooled using a random-effects model.
resultsEleven studies met inclusion: 4 evaluated OTM only, 4 pain only, and 3 both-yielding 7 studies per outcome domain. The meta-analysis for four studies showed no significant difference in pain at 24 h between LIPUS and controls (MD = - 0.76; 95% CI - 2.86 to 1.33; p = 0.48; I
conclusionLIPUS may represent a promising non-invasive adjunct in orthodontics, yet current evidence remains insufficient to support its routine clinical use for either pain management or tooth movement acceleration. Further high-quality randomized controlled trials with standardized application protocols and consistent outcome measures are needed to clarify its effectiveness. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD 420,251,069,418.
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