Evidence map›Paper›PMID 41699514›Full record

ArticleBMC neurology2026

Association of serum HMGB1 and TLR4 levels with early-onset post-stroke depression in type 2 diabetes: a prospective cohort study.

Congcong Wang, Yuan Yi, Zhou Su, Ying Zhao, Yanshuang Hao, Xiaojun Tian, Yumei Wang

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Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Congcong WangDepartment of Neurology, Henan Medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein Modification, The First Affiliated Hospital of Henan Medical University, Xin Xiang, China.
Yuan YiXixian People's Hospital, Xixian, China.
Zhou SuDepartment of Neurology, Henan Medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein Modification, The First Affiliated Hospital of Henan Medical University, Xin Xiang, China.
Ying ZhaoDepartment of Neurology, Henan Medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein Modification, The First Affiliated Hospital of Henan Medical University, Xin Xiang, China.
Yanshuang HaoDepartment of Neurology, Henan Medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein Modification, The First Affiliated Hospital of Henan Medical University, Xin Xiang, China.
Xiaojun TianDepartment of Neurology, Henan Medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein Modification, The First Affiliated Hospital of Henan Medical University, Xin Xiang, China.
Yumei WangDepartment of Neurology, Henan Medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein Modification, The First Affiliated Hospital of Henan Medical University, Xin Xiang, China. yumei2628@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore the relationship between HMGB1 and TLR4 in early-onset post-stroke depression (PSD) among patients with type 2 diabetes mellitus (T2DM).

methodsA cohort of 100 patients diagnosed with T2DM and AIS, admitted to the First Affiliated Hospital of Henan Medical University from January to August 2024, was selected for this study. Based on criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, as well as scores from the Hamilton Depression Rating Scale-17 (HAMD-17), participants were categorized into either a non-PSD group or a PSD group. Logistic regression analysis was utilized to identify risk factors associated with early-onset PSD, while Receiver Operating Characteristic (ROC) curve analysis assessed the diagnostic performance of HMGB1 and TLR4 in predicting PSD among T2DM patients.

resultsUnivariate analysis revealed statistically significant differences in fasting blood glucose levels, serum TLR4 concentrations, and serum HMGB1 levels between both groups (p < 0.05). Logistic regression indicated that both TLR4 and HMGB1 serve as independent and significant risk factors for early-onset PSD in individuals with T2DM. The results from ROC curve analysis demonstrated that the area under the curve (AUC) values for HMGB1, TLR4, and their combined predictive capacity regarding early-onset PSD were 0.786 (95% CI: 0.676-0.897), 0.893 (95% CI: 0.802-0.984), and 0.902 (95% CI: 0.816-0.989).

conclusionElevated serum levels of TLR4 and HMGB1 may be correlated with early-onset PSD in patients suffering from T2DM.

Indexed as

DepressionDiabetes Mellitus, Type 2HMGB1 ProteinStrokeToll-Like Receptor 4AgedBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsBiomarkersHMGB1 ProteinHMGB1 protein, humanTLR4 protein, humanToll-Like Receptor 4HMGB1Post-stroke depressionTLR4Type 2 diabetes mellitus

Identifiers

PMID41699514
PMCPMC13011477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.