ArticleBMC infectious diseases2026
Distinct clinical profiles of nongonococcal gram-negative septic arthritis: a retrospective analysis from a tertiary center.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeptic arthritis is life-threatening, with gram-positive bacteria as the primary cause. However, gram-negative infections are more prevalent in Asia, often resulting in inadequate empirical therapy and higher mortality. The factors linked to gram-negative septic arthritis remain poorly understood. Our aim was to investigate the prevalence, clinical characteristics, and predictive factors of nongonococcal gram-negative septic arthritis in the northeastern region of Thailand.
methodsWe conducted a retrospective study by analyzing medical records from Srinagarind Hospital, a 1,500-bed university hospital in northeastern Thailand, covering the period from January 1, 2015, to October 24, 2024.
resultsA total of 194 patients were included, of whom 67 (34.5%) were infected with gram-negative bacteria. The most common causative agent was Burkholderia pseudomallei (11.3%), followed by Escherichia coli (7.2%). Patients with gram-negative septic arthritis had a greater risk of requiring intensive care unit (ICU) or semi-ICU admission. Multivariate analysis revealed that diabetes mellitus, pyuria, and the absence of bacteria on synovial fluid Gram-stain were significant risk factors for gram-negative septic arthritis. In contrast, hypertension and upper joint involvement were associated with septic arthritis caused by gram-positive bacteria. Additionally, we observed that gram-negative-infected patients were more likely to receive ineffective empirical antibiotics.
conclusionsThis study revealed a greater prevalence of nongonococcal gram-negative septic arthritis in the northeastern region of Thailand. Several risk factors, along with distinct clinical and laboratory characteristics, have been identified, which may help guide the selection of empiric antibiotics for more effective treatment. CLINICAL TRIALS REGISTRY: Retrospectively registered at Thai Clinical Trials Registry. The study was reviewed and approved on 13/02/2025. TCTR identification number is TCTR20250213003.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.