Evidence map›Paper›PMID 41699443›Full record

ArticleAmerican journal of rhinology & allergy2026

Use of Machine Learning and 71-Plex Immune Mediator Analysis to Identify Nasal Mucus Biomarkers Associated With Olfactory Loss in Patients with CRSwNP.

Jason Cory Brunson, Anil Patel, Sufiya Ali, Maria Villanueva, Jeb M Justice, Brian C Lobo, Nikita Chapurin, Carl Atkinson, Jennifer K Mulligan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of rhinology & allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jason Cory BrunsonLaboratory for Systems Medicine, Department of Medicine, University of Florida, Gainesville, Florida.
Anil PatelDepartment of Otolaryngology - Head and Neck Surgery, University of Florida, Gainesville, Florida.
Sufiya AliDepartment of Otolaryngology - Head and Neck Surgery, University of Florida, Gainesville, Florida.
Maria VillanuevaDepartment of Otolaryngology - Head and Neck Surgery, University of Florida, Gainesville, Florida.
Jeb M JusticeDepartment of Otolaryngology - Head and Neck Surgery, University of Florida, Gainesville, Florida.ORCID 0000-0003-4729-028X
Brian C LoboDepartment of Otolaryngology - Head and Neck Surgery, University of Florida, Gainesville, Florida.
Nikita ChapurinDepartment of Otolaryngology - Head and Neck Surgery, University of Florida, Gainesville, Florida.ORCID 0000-0002-3744-0451
Carl AtkinsonDepartment of Surgery, Northwestern University, Chicago, Illinois.
Jennifer K MulliganDepartment of Otolaryngology - Head and Neck Surgery, University of Florida, Gainesville, Florida.ORCID 0000-0001-6880-6092

Funding

Role of Vitamin D Metabolism in CRSR01AI134698 · NIAID · UNIVERSITY OF FLORIDA · PI MULLIGAN, JENNIFER KONOPA · 2018 to 2022
$2.3M
Epithelial cell complement production in the pathogenesis of chronic rhinosinusitisR01AI144364 · NIAID · UNIVERSITY OF FLORIDA · PI ATKINSON, CARL, MULLIGAN, JENNIFER KONOPA · 2020 to 2025
$2.2M
Vitamin D as a modulator of inflammation in CRS-related olfactory lossR01DC022733 · NIDCD · UNIVERSITY OF FLORIDA · PI Jennifer Konopa Mulligan · 2025 to 2026
$985k
NIAID NIH HHS R01 AI134698NIAID NIH HHS R01 AI144364NIDCD NIH HHS R01 DC022733
6 · The paper itself

Abstract

BackgroundThe mechanisms driving chronic rhinosinusitis with nasal polyps (CRSwNP)-related olfactory loss remain largely unknown. Here we sought to identify novel modulators of olfactory function via the examination of nasal mucus biomarkers using an expansive 71-cytokine plex analyzed via machine learning models.MethodsOlfactory testing was performed via 40-question smell identify test (UPSIT). During endoscopic sinus surgery, sponges were placed in the middle meatus of individuals with CRSwNP (

Indexed as

CytokinesMachine LearningMucusNasal MucosaNasal PolypsOlfaction DisordersRhinosinusitisSinusitisAdultBiomarkersChronic DiseaseFemaleHumansMaleMiddle AgedBiomarkersCytokineschronic sinusitismachine learningnasal mucusnasal polypolfactionsinusitisstatistics

Identifiers

PMID41699443
PMCPMC13535564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.