Evidence map›Paper›PMID 41699361›Full record

ArticleObesity surgery2026

Impact of Biopsy-proven Hepatic Fibrosis and Steatohepatitis on Short-term Weight-loss Outcomes after Sleeve Gastrectomy.

Yujie Pu, Zhan Cao, Shiqing Yang, Ke Song, Yutong Chen, Jiajie Xu, Xiaohai Song, Mulusa Fumpa, Qiang Du, Qianyi Wan and 8 more

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Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Yujie PuSichuan University, Chengdu, China.
Zhan CaoSichuan University, Chengdu, China.
Shiqing YangSichuan University, Chengdu, China.
Ke SongSichuan University, Chengdu, China.
Yutong ChenSichuan University, Chengdu, China.
Jiajie XuSichuan University, Chengdu, China.
Xiaohai SongSichuan University, Chengdu, China.
Mulusa FumpaSichuan University, Chengdu, China.
Qiang DuSichuan University, Chengdu, China.
Qianyi WanSichuan University, Chengdu, China.
Xiaoding ShenSichuan University, Chengdu, China.
Rui ZhaoSichuan University, Chengdu, China.
Guixiang ZhangSichuan University, Chengdu, China.
Xiao DuSichuan University, Chengdu, China.
Zhong ChengSichuan University, Chengdu, China.
Jason WidjajaWest China Hospital of Sichuan University, Chengdu, China. drjwbs@yahoo.com.
Haiyang ChenWest China Hospital of Sichuan University, Chengdu, China. chenhy82@scu.edu.cn.
Yi ChenSichuan University, Chengdu, China. toddy@scu.edu.cn.

Funding

Sichuan Province Natural Science Foundation 2023NSFSC0664Sichuan Province Natural Science Foundation 2024NSFSC1695the 1·3·5 Project for Disciplines of Excellence in Artificial Intelligence, West China Hospital, Sichuan University Grant number: ZYAI24024
6 · The paper itself

Abstract

backgroundMetabolic Dysfunction-Associated Steatohepatitis (MASH) and hepatic fibrosis are common in patients undergoing sleeve gastrectomy (SG). Whether histological liver injury influences postoperative weight loss remains uncertain. This study examined the association of biopsy-proven MASH and fibrosis severity with 12-month weight-loss outcomes after SG.

methodsWe retrospectively analyzed 417 patients who underwent SG with intraoperative liver biopsy. Steatosis, inflammation, and ballooning were graded by the NAFLD Activity Score, and fibrosis was staged F0-F4. Weight-loss outcomes included total weight loss (%TWL), excess weight loss (%EWL), and attainment of the expected BMI (eBMI). Logistic regression identified factors associated with eBMI and ≥ 50%EWL achievement.

resultsAt 12 months, patients with MASH and those without achieved comparable percentage of %TWL and %EWL (32.08 vs. 30.23%; 88.64 vs. 93.82%). Fibrosis severity, rather than MASH status, showed an association with individualized BMI attainment, whereas proportional weight-loss outcomes (%TWL and %EWL) did not differ significantly across fibrosis stages.

conclusionsIn this biopsy-confirmed SG cohort, MASH did not affect short-term weight loss, whereas moderate fibrosis was linked to greater likelihood of reaching individualized BMI targets.

Indexed as

Fatty LiverGastrectomyLiver CirrhosisObesity, MorbidWeight LossAdultBiopsyBody Mass IndexFemaleHumansLiverMaleMiddle AgedRetrospective StudiesTreatment OutcomeExpected BMIHepatic fibrosisMetabolic-associated steatohepatitisSleeve gastrectomyWeight loss outcomes

Identifiers

PMID41699361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.