Evidence map›Paper›PMID 41699329›Full record

ArticleClinical oral investigations2026

Potential for vertical control using direct 3D‑printed mandibular advancement clear aligners.

Yifan Wang, Yana Wen, Zhihang Song, Chen Zhang, Guanyin Zhu, Zhihe Zhao

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Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yifan Wang *State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Yana Wen *State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Zhihang SongState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Chen ZhangState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Guanyin ZhuState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China. gyzhu@scu.edu.cn.ORCID http://orcid.org/0000-0002-8893-7046
Zhihe ZhaoState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China. zhzhao@scu.edu.cn.ORCID http://orcid.org/0000-0003-2955-1706

Funding

National Natural Science Foundation of China 32271416National Natural Science Foundation of China 82401171Science and Technology Program 2024YFFK0295
6 · The paper itself

Abstract

objectivesTo evaluate the biomechanical performance of the direct 3D‑printed monoblock mandibular advancement clear aligner (MACA) designs intended for different vertical control objectives via finite element analysis (FEA). MATERIALS AND

methodsAn FEA model was constructed from CBCT and intraoral scans of a 12-year-old Class II patient. To isolate design-dependent effects, three monoblock MACA designs for different vertical control objectives were tested on this single, morphology‑controlled skeletal model. Passive tension from six craniofacial muscles was simulated during occlusal reconstruction. Appliance deformation, mandibular displacement, and tooth movement were analyzed.

resultsAll three MACAs demonstrated satisfactory manufacturability and maintained stable mandibular advancement under muscular tension. Low-angle MACA intruded lower incisors while creating posterior interocclusal space that may be permissive for subsequent vertical adaptation under clinical conditions, aligning with treatment objectives for low‑angle cases. Lower incisor labial inclination was observed, which could be mitigated by localized appliance thickening. Average-angle MACA intruded anterior teeth while maintaining posterior height and mandibular plane angle. High-angle MACA induced molar intrusion. When combined with targeted anterior intrusion, this dual mechanism provided precise vertical control and may be associated with counterclockwise mandibular rotation.

conclusionsThis study demonstrates the design capability of direct 3D‑printed MACAs and proposes preliminary design principles for customized MACAs addressing different vertical treatment objectives. CLINICAL RELEVANCE: This study provided preliminary design principles for customized MACAs. Pattern-specific MACA designs may inform treatment strategies, but clinical validation through studies incorporating true anatomical variation across different vertical skeletal patterns is essential before clinical application.

Indexed as

Malocclusion, Angle Class IIMandibular AdvancementOrthodontic Appliance DesignPrinting, Three-DimensionalBiomechanical PhenomenaChildCone-Beam Computed TomographyFinite Element AnalysisHumansClear alignersFinite element analysisMandibular advancementOrthodontic biomechanics

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.