Evidence map›Paper›PMID 41699266›Full record

ArticleJournal of gastroenterology2026

Multicenter retrospective analysis of primary small intestinal lymphoma in Japan.

Masafumi Kitamura, Tomonori Yano, Shiro Oka, Takehiro Torisu, Akio Shiomi, Kinichi Hotta, Fumio Ishida, Shin-Ei Kudo, Takeshi Yamada, Keigo Mitsui and 47 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors.

Masafumi KitamuraDepartment of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan.
Tomonori YanoDepartment of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Takehiro TorisuDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Akio ShiomiDivision of Colon and Rectal Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Kinichi HottaDivision of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Fumio IshidaDigestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan.
Shin-Ei KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan.
Takeshi YamadaDepartment of Gastroenterological Surgery, Nippon Medical School, Tokyo, Japan.
Keigo MitsuiDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Masazumi OkajimaDepartment of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Toshio UraokaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Gunma, Japan.
Hiroaki NozawaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Koichi KuraharaDivision of Gastroenterology, Matsuyama Red Cross Hospital, Ehime, Japan.
Hiroaki IkematsuDepartment of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan.
Masaaki ItoDepartment of Colorectal Surgery, National Cancer Center Hospital East, Chiba, Japan.
Keiichi TakahashiDepartment of Colorectal Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Shoichi SaitoDepartment of Lower Gastrointestinal Medicine, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Masashi UenoDepartment of Gastroenterological Surgery, Toranomon Hospital, Tokyo, Japan.
Shigeki YamaguchiDepartment of Gastroenterological Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
Yasumori FukaiDepartment of Gastroenterology, Maebashi Red Cross Hospital, Gunma, Japan.
Toshio KuwaiDepartment of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.
Shinji NagataDepartment of Gastroenterology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Tomohiro KatoDepartment of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan.
Yoji TakeuchiDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Yojiro HashiguchiDepartment of Surgery, Japanese Red Cross Omori Hospital, Tokyo, Japan.
Naoki OhmiyaDepartment of Advanced Endoscopy, Fujita Health University School of Medicine, Aichi, Japan.
Tomoki YamanoDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo Medical University, Hyogo, Japan.
Michio ItabashiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Eiji SunamiDepartment of Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Eigo OtsujiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Hiroyuki TakamaruEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan.
Tamotsu SugaiDepartment of Diagnostic Pathology, Iwate Medical University, Iwate, Japan.
Masaya KawaiDepartment of Coloproctological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Takashi YaoDepartment of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Tetsuji TakayamaDepartment of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Eiji ShintoDepartment of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
Kazuo OhtsukaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Kenichi SugiharaTokyo Medical and Dental University, Tokyo, Japan.
Motohiro EsakiDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Takeshi KatoDepartment of Surgery, NHO Osaka National Hospital, Osaka, Japan.
Kazutomo TogashiDepartment of Coloproctology, Aizu Medical Center, Fukushima Medical University, Fukushima, Japan.
Yoshito AkagiDepartment of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
Hiroshi KashidaDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.
Takahiro HorimatsuDepartment of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.
Yusuke SaitohDepartment of Gastroenterology, Asahikawa City Hospital, Asahikawa, Hokkaido, Japan.
Kazutaka YamadaDepartment of Surgery, Coloproctology Center Takano Hospital, Kumamoto, Japan.
Keiji KodaDepartment of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
Madoka HamadaDepartment of Gastrointestinal Surgery, Kansai Medical University Hospital, Osaka, Japan.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
Akira ToyoshimaDepartment of Colorectal Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Shinji TanakaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Hironori YamamotoDepartment of Endoscopic Research and International Education, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. yamamoto@jichi.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary small intestinal lymphoma (PSIL) is a rare disease, and its clinical characteristics and prognostic factors remain insufficiently defined because of limited large-scale data.

methodsWe conducted a nationwide multicenter retrospective study of 686 patients diagnosed with PSIL between January 2008 and December 2017 at 44 institutions in Japan. Clinical characteristics, histological subtypes, and overall survival were analyzed.

resultsB-cell lymphoma was the predominant immunophenotype (n = 623, 91%), whereas T-cell lymphoma was uncommon (n = 50, 7%). Diffuse large B-cell lymphoma (DLBCL) was the most frequent histological subtype (n = 330, 48%), followed by follicular lymphoma (FL) (n = 224, 33%). Compared with other B-cell lymphomas, FL was more common in women and more frequently involved the jejunum (P < 0.001). The 5-year overall survival rate was significantly higher in patients with B-cell lymphoma than in those with T-cell lymphoma (81% vs. 23%, P < 0.001). Multivariate Cox regression analysis identified age > 60 years and T-cell lymphoma as independent adverse prognostic factors, whereas FL was an independent predictor of favorable overall survival.

conclusionsThis nationwide multicenter analysis delineates the clinicopathological features and survival outcomes of PSIL in Japan. FL represents the second most common subtype after DLBCL and is associated with a favorable prognosis among PSIL subtypes.

Indexed as

Intestinal NeoplasmsIntestine, SmallLymphoma, B-CellLymphoma, FollicularLymphoma, Large B-Cell, DiffuseLymphoma, T-CellAdultAgedAged, 80 and overAge FactorsFemaleHumansJapanMaleMiddle AgedPrognosisClinical characteristicsFollicular lymphomaPrimary small intestinal lymphomaPrognosisT-cell lymphoma

Identifiers

PMID41699266

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