Evidence map›Paper›PMID 41699257›Full record

ArticleCommunications biology2026

Imaging mass cytometry unveils functional and spatial remodeling of peri-lesional cells in jaw osteonecrosis.

Jiazheng Cai, Ying Xue, Stian Tornaas, Harsh Nitin Dongre, Athanasia Bletsa, Sigbjørn Løes, Peter Schleier, Evelyn Neppelberg, Arild Kvalheim, Ellen Berggreen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiazheng Cai *Department of Medical Biology, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.ORCID http://orcid.org/0009-0008-5148-1787
Ying Xue *Department of Clinical Dentistry, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.ORCID http://orcid.org/0000-0002-2266-3839
Stian TornaasGade Laboratory for Pathology and Norwegian Center for Cancer Biomarkers CCBIO, Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway.
Harsh Nitin DongreGade Laboratory for Pathology and Norwegian Center for Cancer Biomarkers CCBIO, Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-4378-2869
Athanasia BletsaDepartment of Clinical Dentistry, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-2427-8165
Sigbjørn LøesDepartment of Clinical Dentistry, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.ORCID http://orcid.org/0000-0001-7941-4908
Peter SchleierDepartment of Otolaryngology, Stavanger University Hospital, Stavanger, Norway.ORCID http://orcid.org/0000-0002-0249-154X
Evelyn NeppelbergDepartment of Clinical Dentistry, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-3711-6168
Arild KvalheimOris Dental Tannteam Secialist Clinic, Nesttun, Norway.
Ellen BerggreenDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0001-6077-943X
Daniela-Elena CosteaGade Laboratory for Pathology and Norwegian Center for Cancer Biomarkers CCBIO, Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0001-7673-0358
Zhe XingDepartment of Medical Biology, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway. zhe.xing@uit.no.ORCID http://orcid.org/0000-0002-7419-2012
Anca VirtejDepartment of Clinical Dentistry, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.ORCID http://orcid.org/0000-0001-5918-3663

Funding

Helse Vest (Western Norway Regional Health Authority) 912222Helse Vest (Western Norway Regional Health Authority) F-13105Norges Forskningsråd (Research Council of Norway) 22325Wellcome Trust 102728
6 · The paper itself

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive therapy, characterized by compromised bone and soft tissue integrity. However, the underlying tissue-level mechanisms remain poorly understood. To uncover cell functions and spatial organization surrounding ONJ lesions, imaging mass cytometry is used to profile lesions at single-cell resolution across epithelial, stromal, and vascular regions. Widespread immune infiltration is observed, with regulatory T cells, M2-like macrophages, exhausted T cells, and natural killer cells shifting from dispersed to clustered spatial patterns, indicating altered immune organization. Epithelial regions show reduced epithelial marker expression and disrupted architecture despite elevated proliferation-related markers, while fibroblasts and endothelial cells display signs of activation. Functional profiling reveals concurrent proliferative, apoptotic, and stress-associated signatures across multiple cell populations. This comprehensive spatial and functional atlas provides insights into the pathophysiology of MRONJ and may inform future therapeutic strategies aimed at restoring tissue homeostasis and promoting effective healing.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawImage CytometryAnimalsHumansMacrophages

Identifiers

PMID41699257
PMCPMC13021915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.