Articlenpj antimicrobials and resistance2026
Functional characterization of macrolide esterase from cyanobacteria and their potential dissemination risk.
Article in npj antimicrobials and resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The global dissemination of antibiotic resistance genes (ARGs) across diverse environments has emerged as a critical challenge to public health. As essential primary producers, Cyanobacteria colonize extreme and heterogeneous habitats, coexisting with gut microbiota in wastewater, marine ecosystems, and reservoirs, where they may potentiate the proliferation and transmission of ARGs under antibiotic selective pressures. In this study, three macrolide esterases (NOD-1, OCA-1, and OCB-1) of Cyanobacterial origin were identified through mining of local genomic repositories. These enzymes, classified as serine-dependent alpha/beta -hydrolases, were experimentally validated through antimicrobial susceptibility testing and zone of inhibition assays to inactivate specific 16-membered macrolide antibiotics. Comparative analysis of genomic regions flanking these resistance determinants revealed the presence of mobile genetic elements (MGEs) and co-localized multidrug resistance genes, strongly suggesting the likelihood of horizontal gene transfer (HGT) within Cyanobacterial populations. Such genetic mobility may exacerbate antibiotic resistance dissemination in aquatic ecosystems, underscoring the ecological risks posed by Cyanobacteria as reservoirs and vectors of ARGs.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.