Evidence map›Paper›PMID 41699245›Full record

Trial reportEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Effects of electrical stimulation rate in genetically confirmed pre- and post-Synaptic auditory neuropathy in children.

Majid Karimi, Mohsen Ahadi, Mohammad Ajalloueyan, Nader Saki, Saeid Morovvati, Golshan Mirmomeni

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Majid KarimiRehabilitation Research Centre, Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences (IUMS), Tehran, Iran.ORCID http://orcid.org/0009-0009-6251-4561
Mohsen AhadiRehabilitation Research Centre, Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences (IUMS), Tehran, Iran. ahadi.m@iums.ac.ir.ORCID http://orcid.org/0000-0002-8591-2361
Mohammad AjalloueyanDepartment of Otorhinolaryngology, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-0952-0400
Nader SakiDepartment of Otolaryngology, Head and Neck Surgery, Hearing Research Center, Ahvaz Jundishapur University of Medical Sciences, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.ORCID https://orcid.org/0000-0003-4564-6406
Saeid MorovvatiSchool of Advanced Sciences and Technology, Islamic Azad University-Tehran Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-8838-1044
Golshan MirmomeniHearing Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.ORCID https://orcid.org/0000-0002-5126-3682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAuditory Neuropathy Spectrum Disorder (ANSD) affects neural transmission of auditory signals and is classified into presynaptic and postsynaptic types. Cochlear implant (CI) outcomes depend on lesion site and stimulation rate, with slower rates potentially benefiting impaired conduction.

methodsSeventy children aged 2-7 years with genetically confirmed ANSD received the Nucleus CI system. Participants were grouped as either pre- or post-synaptic and randomly assigned to one of three stimulation rates: 500, 900, or 1800 pulses per second (PPS). Assessments at 3 and 6 months included aided thresholds, Persian versions of the Categories of Auditory Performance (CAP) and Speech Intelligibility Rating (SIR), cortical P1 latency and amplitude, and Electrically Evoked Compound Action Potential (ECAP) via Neural Response Telemetry across apical, mid, and basal electrodes.

resultDespite comparable aided thresholds, presynaptic ANSD cases showed consistent ECAP responses and greater improvements in P1 measures and CAP/SIR scores, particularly at low and moderate rates. ECAP amplitude increased and latency decreased over time in this group, with no significant rate-time interaction. Postsynaptic cases showed limited ECAP responses and smaller functional gains.

conclusionLesion site critically influences CI outcomes in ANSD. Presynaptic children demonstrated physiological and functional improvements, especially at lower rates, consistent with preserved neural integrity. Postsynaptic cases showed restricted responses, likely reflecting demyelination. Findings support individualized CI programming guided by genetic and neural profiles.

Indexed as

Cochlear ImplantationCochlear ImplantsElectric StimulationHearing Loss, CentralAuditory ThresholdChildChild, PreschoolEvoked Potentials, AuditoryFemaleHumansMaleSpeech IntelligibilityAuditory neuropathy spectrum disorder (ANSD)Cochlear implantationElectrically evoked compound action potential (ECAP)Speech and auditory outcomesStimulation rate

Identifiers

PMID41699245

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.