Evidence map›Paper›PMID 41699171›Full record

ReviewPediatric nephrology (Berlin, Germany)2026

Treatment outcomes and ongoing pediatric trials in steroid-resistant nephrotic syndrome.

Chris K Fan, Heather S Jung, Yasmine E Pang, Chia-Shi Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chris K FanDivision of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Heather S JungDivision of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Yasmine E PangDivision of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Chia-Shi WangDivision of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. chia-shi.wang@emory.edu.ORCID http://orcid.org/0000-0001-6941-0057

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite an increasing number of therapeutic options for pediatric patients with steroid-resistant nephrotic syndrome (SRNS), treatment resistance and risk of progression to kidney failure are still high. Children with monogenic forms of SRNS and resistance to non-steroidal immunosuppressants are at the highest risk. Advances in the understanding of SRNS pathogenesis have enabled the development of novel therapies that target genetic, immunologic, and metabolic mechanisms of disease development and progression. In this review, we summarize select contemporary cohort study findings, novel therapeutic agents and their mechanistic targets, and eight recent and ongoing clinical trials for pediatric patients with SRNS.

Indexed as

GlucocorticoidsImmunosuppressive AgentsNephrotic SyndromeChildClinical Trials as TopicDisease ProgressionDrug ResistanceHumansTreatment OutcomeGlucocorticoidsImmunosuppressive AgentsChildFocal segmental glomerulosclerosisGlomerulonephritisImmunosuppressive agentsNephrotic syndromePrecision medicinePrognosis

Identifiers

PMID41699171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.