ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Comparison of the prognosis of asphyxiated infants receiving hypothermia therapy with those receiving erythropoietin: a prospective cohort study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlthough Therapeutic Hypothermia in the last two decades promises hope in reducing the problems of asphyxiated babies in developed countries, it is still not available in most parts of the world, and the results available in developing countries are not promising.
objectiveIn this study, we aimed to compare Hypoxic Ischemic Encephalopathy (HIE) infants receiving total hypothermia (TH) and erythropoietin (EPO).
methodsIn a prospective cohort study, we compared the developmental prognosis of infants with HIE receiving TH (control group, N = 26) with those receiving EPO (case group, N = 34). The severity of acidosis, Apgar score of the first and fifth minutes, seizures, ventilation, and development at the age of two years on the Denver 2 test was compared between two groups.
resultsThe type of delivery, weight, Apgar score in the first minute, and severity of HIE, PH, and HCO3 were homogeneous in the two study groups. No statistically significant difference was observed between the babies in the two study groups in terms of severity of HIE (P = 0.649). Forthy-six percent of the infants in the TH group and 24% of the infants in the EPO group died before age two (P = 0.097). Of the live infants discharged, 24% of the TH group and 35% of the EPO group had developmental delay (P = 0.478). Sixty-five percent of the infants in the TH group and 44% of the EPO group had an unfavorable prognosis at the age of two years (p = 0.123).
conclusionsThe comparison of TH with EPO prescription in infants with moderate to severe HIE showed that the adverse neurological outcome and death did not show a significant difference between the two groups. Therefore, in areas where TH is not available, the use of erythropoietin as a neuroprotection may be satisfying.
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