ArticleArchives of virology2026
Biological characterization and genomic analysis of Kpp-61, a lytic bacteriophage against K1-type Klebsiella pneumoniae.
Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Klebsiella pneumoniae (K. pneumoniae) is a leading cause of both nosocomial and community-acquired infections. In this study, we isolated a lytic bacteriophage (phage), designated Kpp-61, targeting K. pneumoniae with capsular serotype K1, which is prevalent in hypervirulent strains. Transmission electron microscopy showed that Kpp-61 had an icosahedral head and a non-contractile short tail. In vitro, Kpp-61 demonstrated significant antibiofilm activity, inhibiting biofilm formation and disrupting preformed biofilms. Furthermore, in a murine infection model, Kpp-61 improved the 7-day survival rate of mice to 60% and 90% at MOIs of 10 and 100, respectively, and mitigated pneumonia symptoms in K. pneumoniae strain Kp61-infected mice. Notably, Kpp-61 exhibited high specificity for K1-serotype strains, along with robust thermal and pH stability. Genomic analysis revealed a circular double-stranded DNA genome of 44,028 bp, with a G + C content of 50.28% and 54 predicted open reading frames. Crucially, no virulence or antibiotic-resistance genes were detected. These results indicate the therapeutic potential of phage Kpp-61 against K1-serotype K. pneumoniae infections.
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