ArticleClinical oral investigations2026
Impact of drug-induced immunosuppression following kidney transplantation on periodontal health and the periodontal microbiome: a longitudinal controlled study.
Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe conducted longitudinal controlled clinical study aimed to determine the microbiological and clinical periodontal changes in patients with chronic kidney disease before and after kidney transplantation and its associated drug-induced immunosuppression. MATERIALS AND
methodsBaseline radiological, clinical, and microbiological evaluations of fifteen kidney recipients and donors were performed prior to kidney transplantation, with six weeks and six months follow-up assessments. Clinical evaluations included periodontal probing depth (PPD), bleeding on probing (BOP), and clinical attachment loss (CAL) for kidney donors and recipients. Microbiological analysis was performed on samples from the deepest periodontal pockets, analyzed by next-generation sequencing.
resultsIn kidney recipients, there was a reduction for BOP six weeks post-transplant, followed by an increase at six months, along with an improvement in CAL scores and a reduction in the deepest probing depths. Alpha diversity decreased significantly (p = 0.0311), while beta diversity changed significantly, indicating substantial changes in the bacterial community structure (p = 0.001), with a notable decrease in Aggregatibacter and Porphyromonas, correlating with immunosuppressive therapy. In kidney donors, there were no significant changes in alpha and beta diversity but shifts in the relative abundance of certain bacterial genera were noted.
conclusionsImmunosuppressive therapy after kidney transplantation effects periodontal health and microbiome composition. Kidney recipients showed initial improvements in periodontal health but did not maintain these changes long-term. CLINICAL RELEVANCE: The findings highlight the importance of regular periodontal care in transplant patients and further longitudinal studies. The trial was registered in the German Clinical Trials Register (DRKS-ID: DRKS00031639) (05/04/2023).
Indexed as
Identifiers
41699131What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.