ArticleScientific reports2026
Copper catalyzed synthesis of thiazole derivatives from enaminones, amines and CS₂.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An efficient copper-catalyzed method for the synthesis of thiazoles from enaminones, amines, and carbon disulfide (CS₂) is described. This one-pot, ligand- and additive-free protocol proceeds under relatively simple reaction conditions, affording thiazole derivatives in good to excellent yields. Notably, CS₂ serves as a combined sulfur and carbon source, contributing to the synthetic practicality of the transformation. The method demonstrates good functional-group tolerance and provides a straightforward approach to biologically relevant thiazole scaffolds.
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