ArticleScientific reports2026
Altered expression of the CD26/ADA axis in immune-mediated inflammation of infectious mononucleosis.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Infectious mononucleosis (IM), a common disease in children, was often accompanied by excessive inflammatory response and organ damage. This study aimed to explore the CD26/ADA axis in the pathogenesis of acute Epstein-Barr virus (EBV)-associated IM. Thirty children with acute IM and thirty age-matched controls from Children’s Hospital of Soochow University were enrolled in this study. The CD26 and adenosine deaminase (ADA) mRNA were detected by real-time PCR in the peripheral blood. Meanwhile, the levels of plasma interferon gamma (IFN-γ), interleukin (IL)-4 and IL-10 were measured by ELISA, and the frequency of CD26-positive cells in CD4+ T cells and CD8+ T cells was analyzed by flow cytometry. Children with acute IM had significantly higher expression levels of CD26 mRNA and ADA mRNA than control group in peripheral blood (P < 0.05). Plasma IL-4, IL-10 and INF-γ level were markedly elevated compared to the control group (P < 0.05). Furthermore, the plasma CD26 protein level was positively correlated with ADA (r = 0.610, P<0.01) and INF-γ (r = 0.417, P = 0.022), and negatively correlated with the percentage of CD3+ CD4+ T cell (r = -0.446, P = 0.014) and CD4+ /CD8+ ratio (r = -0.414, P = 0.023) in acute IM group. In addition, the frequency of CD26-positive cells was elevated on CD8+ T cells but markedly decreased on CD4+ CD39+ regulatory T cells (P < 0.05). The peripheral blood CD26 and ADA mRNA levels were elevated in acute IM. Moreover, CD26 exhibited cell-specific alterations, being increased on CD8+ T cells but reduced on CD4+ CD39+ Tregs.
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